| Targeted complement inhibition as a promising strategy for preventing inflammatory complications in hemodialysis. | |
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MedLine Citation:
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PMID: 22964235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hemodialysis is the most common method used to remove waste and hazardous products of metabolism in patients suffering from renal failure. Hundreds of thousands of people with end-stage renal disease undergo hemodialysis treatment in the United States each year. Strikingly, the 5-year survival rate for all dialysis patients is only 35%. Most of the patients succumb to cardiovascular disease that is exacerbated by the chronic induction of inflammation caused by contact of the blood with the dialysis membrane. The complement system, a strong mediator of pro-inflammatory networks, is a key contributor to such biomaterial-induced inflammation. Though only evaluated in experimental ex vivo settings, specific targeting of complement activation during hemodialysis has uncovered valuable information that points toward the therapeutic use of complement inhibitors as a means to control the unwelcomed inflammatory responses and consequent pathologies in hemodialysis patients. |
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Authors:
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Robert A DeAngelis; Edimara S Reis; Daniel Ricklin; John D Lambris |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Immunobiology Volume: 217 ISSN: 1878-3279 ISO Abbreviation: Immunobiology Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-09-11 Completed Date: 2013-03-14 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8002742 Medline TA: Immunobiology Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1097-105 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier GmbH. All rights reserved. |
Affiliation:
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Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biocompatible Materials Cardiovascular Diseases / etiology, immunology Complement Activation* Complement Inactivator Proteins* Complement System Proteins / immunology, metabolism* Humans Inflammation / etiology, immunology, pathology, prevention & control* Kidney Failure, Chronic / blood, therapy Molecular Targeted Therapy Renal Dialysis / adverse effects* |
| Grant Support | |
ID/Acronym/Agency:
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AI068730/AI/NIAID NIH HHS; AI30040/AI/NIAID NIH HHS; GM097747/GM/NIGMS NIH HHS; P01 AI068730/AI/NIAID NIH HHS; R01 AI030040/AI/NIAID NIH HHS; R01 EY020633/EY/NEI NIH HHS; R01 GM097747/GM/NIGMS NIH HHS; Y020633//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Complement Inactivator Proteins; 9007-36-7/Complement System Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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