Document Detail

Targeted agents in non-small cell lung cancer (NSCLC): Clinical developments and rationale for the combination with thoracic radiotherapy.
MedLine Citation:
PMID:  22196919     Owner:  NLM     Status:  Publisher    
In recent years there has been undoubted progress in the evaluation and development of targeted agents for non-small cell lung cancer (NSCLC). A major contributor has been the discovery of molecular subtypes harbouring a critical oncogenic driver mutation, specifically sensitizing mutations in the epidermal growth factor receptor (EGFR) gene and the EML4-ALK gene translocation. Radiotherapy is a cornerstone of therapy for the curative intent treatment of early stage, localized disease; and for the palliation of symptoms in advanced, metastatic disease. In this molecular targeted era there is limited understanding of how best to combine targeted agents with radiotherapy and in general clinical studies with radiotherapy have lagged behind studies of targeted agents with chemotherapy. Here we summarise the progress made to date and highlight future directions.
Pek Keng Koh; Corinne Faivre-Finn; Fiona H Blackhall; Dirk De Ruysscher
Related Documents :
24160289 - Non-melanoma skin cancers: photodynamic therapy, cryotherapy, 5-fluorouracil, imiquimod...
11834019 - Characteristics and prognosis of resected t3 non-small cell lung cancer.
23913109 - Surgery of recurrent brain metastases: retrospective analysis of 67 patients.
22173049 - Skin metastases in nonsmall cell lung cancer.
24649199 - Survival study and clinicopathological evaluation of trichilemmal carcinoma.
19620539 - Increased lymph node evaluation with colorectal cancer resection: does it improve detec...
11062719 - Prognostic relevance of urokinase type plasminogen activator, its receptor and inhibito...
25190119 - A novel method for intraoperative sentinel lymph node detection in prostate cancer pati...
65209 - Radiotherapy and rectal cancer.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-22
Journal Detail:
Title:  Cancer treatment reviews     Volume:  -     ISSN:  1532-1967     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7502030     Medline TA:  Cancer Treat Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ltd.
Department of Clinical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Impact of a change of computer software on prescription drug errors in an emergency department.
Next Document:  Forest carbon stocks and fluxes in physiographic zones of India.