| Targeted venous occlusion using pulsed high-intensity focused ultrasound. | |
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MedLine Citation:
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PMID: 19709959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Targeted vascular occlusion is desirable for clinical therapies such as in the treatment of esophageal and gastric varices and varicose veins. The feasibility of ultrasound-mediated endothelial damage for vascular occlusion was studied. A segment of a rabbit auricular vein was treated in vivo with low duty cycle, high peak rarefaction pressure (9 MPa) high-intensity focused ultrasound pulses in the presence of intravenously administered circulating microbubbles, followed by fibrinogen injection, which resulted in the formation of an acute occlusive intravascular thrombus. Further investigation and refinements of treatment protocols are necessary for producing durable vascular occlusion. |
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Authors:
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Joo Ha Hwang; Yufeng Zhou; Cinderella Warren; Andrew A Brayman; Lawrence A Crum |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-08-25 |
Journal Detail:
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Title: IEEE transactions on bio-medical engineering Volume: 57 ISSN: 1558-2531 ISO Abbreviation: IEEE Trans Biomed Eng Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-12 Completed Date: 2010-03-30 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0012737 Medline TA: IEEE Trans Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 37-40 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, Department ofMedicine, Center for Industrial and Medical Ultrasound, Applied PhysicsLaboratory, University of Washington, Seattle, WA 98195, USA. jooha@medicine.washington.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Coagulation / drug effects Contrast Media / administration & dosage Ear / blood supply Endothelium, Vascular / drug effects, injuries Fibrinogen / administration & dosage High-Intensity Focused Ultrasound Ablation / methods* Histocytochemistry Rabbits Thrombosis / chemically induced, etiology*, ultrasonography |
| Grant Support | |
ID/Acronym/Agency:
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K08 DK069622/DK/NIDDK NIH HHS; K08 DK069622-04/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 9001-32-5/Fibrinogen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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