| Targeted O2 delivery by blood substitutes: in vitro arteriolar simulations of first- and second-generation products. | |
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MedLine Citation:
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PMID: 18671987 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The O(2) transport from mixtures of commercially produced hemoglobin-based O(2) carriers (HBOCs) and red blood cells (RBCs) flowing through arteriolar-sized (25-mum) conduits is simulated. A generalized treatment of extraluminal O(2) transport processes is used to reflect variations in physiological conditions, such as increased O(2) consumption. Of the HBOCs considered, polymerized bovine hemoglobin (PolyBvHb, p50=54 mmHg), tetrameric cross-linked human hemoglobin (alphaalphaHb, p50=33 mmHg), and PEGylated human hemoglobin (MP4, p50=5 mmHg), only MP4 does not increase O(2) extraction ratios when compared to RBC suspensions alone. A reduction in arteriolar O(2) extraction is likely to be beneficial for HBOCs by preventing O(2)-induced vasoactivity and maximizing the supply of O(2) available to the capillaries. Results from in vivo HBOC transfusion experiments cannot be predicted by the model, unless PolyBvHb has a significant decrease in extraluminal O(2) transport resistance as compared to MP4. This result is consistent with the literature that shows arteriolar O(2) consumption to increase with intravascular pO(2). |
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Authors:
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Russell Cole; Kim Vandegriff; Andrew Szeri; Omer Savas; Robert Winslow |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article Date: 2008-07-11 |
Journal Detail:
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Title: Microvascular research Volume: 76 ISSN: 1095-9319 ISO Abbreviation: Microvasc. Res. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-22 Completed Date: 2009-01-28 Revised Date: 2010-09-21 |
Medline Journal Info:
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Nlm Unique ID: 0165035 Medline TA: Microvasc Res Country: United States |
Other Details:
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Languages: eng Pagination: 169-79 Citation Subset: IM |
Affiliation:
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Department of Mechanical Engineering, 140 Hesse Hall, University of California, Berkeley, California 94720, USA. Russell@me.berkeley.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterioles / physiology Blood Substitutes / chemistry, metabolism* Cattle Erythrocytes / metabolism Hemoglobins / metabolism Humans Kinetics Microcirculation Models, Biological Models, Cardiovascular Oxygen / blood* Polyethylene Glycols / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL076163-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Substitutes; 0/Hemoglobins; 0/PEG-Hb conjugate, MP4; 0/Polyethylene Glycols; 0/polyhemoglobin; 7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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