Document Detail

Target organ directed drug delivery: evaluation of renal infusion of chromium-51 ethylenediaminetetraacetate and sodium o-[125I]iodohippurate in the Wistar Kyoto rat.
MedLine Citation:
PMID:  3104576     Owner:  NLM     Status:  MEDLINE    
To evaluate the merits of intrarenal drug delivery, the disposition of chromium-51 ethylenediaminetetraacetate (51Cr EDTA) and sodium o-[125I]iodohippurate (125I OIH) was studied following their constant-rate infusion into either the jugular vein or the left or right renal artery of Wistar Kyoto rats. The contralateral kidney was removed. Renal blood flow through the lateral kidney was measured during the experiment via an electromagnetic flow probe. Urine and systemic arterial blood samples were taken at steady state. The clearance and extraction of both substances by the right kidney were independent of the route of administration. Nonlinear kinetics were observed during infusion of 125I OIH at the highest infusion rate in the left kidney. At steady state the advantage of intrarenal over systemic delivery was limited because of the relative high blood flow of the kidney. Only a small reduction (30%) in systemic concentration was achieved by infusion of 51Cr EDTA. Intrarenal infusion of the lower dose (10 nCi/min) of 125I OIH reduced the systemic concentration by greater than 80% when compared with systemic infusion. Intrarenal infusion of the higher dose (40 nCi/min) saturated elimination processes in parts of the left kidney because of nonhomogeneous flow distribution.
M J Daemen; H H Thijssen; H van Essen; J F Smits; H A Struyker-Boudier
Related Documents :
434486 - Halothane-induced renal vasodilation.
6367016 - The outer surface morphology of blood vessels as revealed in scanning electron microsco...
2155546 - Diluting segment in kidney of dogfish shark. i. localization and characterization of ch...
12392086 - Contribution of nitric oxide to potassium bromate-induced elevation of methaemoglobin c...
9740436 - The effects of a copper-intrauterine device on the uterine artery blood flow in regular...
8169096 - Color doppler ultrasound of changes in small vessel diameter and cerebral blood flow du...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  75     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-05-07     Completed Date:  1987-05-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1137-40     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Edetic Acid / administration & dosage*
Injections, Intra-Arterial
Injections, Intravenous
Iodohippuric Acid / administration & dosage*
Jugular Veins
Kidney / metabolism*
Metabolic Clearance Rate
Rats, Inbred WKY
Renal Artery
Reg. No./Substance:
147-58-0/Iodohippuric Acid; 60-00-4/Edetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Plasma levels of immunoreactive melatonin, estradiol, progesterone, follicle stimulating hormone, an...
Next Document:  Characterization of liposomes and an emulsion containing mitomycin C or lipophilic mitomycin C prodr...