Document Detail


Target organ directed drug delivery: evaluation of renal infusion of chromium-51 ethylenediaminetetraacetate and sodium o-[125I]iodohippurate in the Wistar Kyoto rat.
MedLine Citation:
PMID:  3104576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the merits of intrarenal drug delivery, the disposition of chromium-51 ethylenediaminetetraacetate (51Cr EDTA) and sodium o-[125I]iodohippurate (125I OIH) was studied following their constant-rate infusion into either the jugular vein or the left or right renal artery of Wistar Kyoto rats. The contralateral kidney was removed. Renal blood flow through the lateral kidney was measured during the experiment via an electromagnetic flow probe. Urine and systemic arterial blood samples were taken at steady state. The clearance and extraction of both substances by the right kidney were independent of the route of administration. Nonlinear kinetics were observed during infusion of 125I OIH at the highest infusion rate in the left kidney. At steady state the advantage of intrarenal over systemic delivery was limited because of the relative high blood flow of the kidney. Only a small reduction (30%) in systemic concentration was achieved by infusion of 51Cr EDTA. Intrarenal infusion of the lower dose (10 nCi/min) of 125I OIH reduced the systemic concentration by greater than 80% when compared with systemic infusion. Intrarenal infusion of the higher dose (40 nCi/min) saturated elimination processes in parts of the left kidney because of nonhomogeneous flow distribution.
Authors:
M J Daemen; H H Thijssen; H van Essen; J F Smits; H A Struyker-Boudier
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  75     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-05-07     Completed Date:  1987-05-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1137-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Edetic Acid / administration & dosage*
Injections, Intra-Arterial
Injections, Intravenous
Iodohippuric Acid / administration & dosage*
Jugular Veins
Kidney / metabolism*
Kinetics
Male
Metabolic Clearance Rate
Rats
Rats, Inbred WKY
Renal Artery
Chemical
Reg. No./Substance:
147-58-0/Iodohippuric Acid; 60-00-4/Edetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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