Document Detail

Target-controlled infusion of propofol in dogs--evaluation of four targets for induction of anaesthesia.
MedLine Citation:
PMID:  16339979     Owner:  NLM     Status:  MEDLINE    
Four groups of 20 dogs were anaesthetised by means of target-controlled infusions of propofol designed to achieve 2.5 microg/ml, 3.0 microg/ml, 3.5 microg/ml or 4.0 microg/ml of propofol in blood. The dogs' pulse rate and respiratory rate were recorded before premedication and induction, immediately after endotracheal intubation and three and five minutes later (times 0, 3 and 5, respectively), and their arterial blood pressure was recorded oscillometrically just before induction and at times 0, 3 and 5. The targets of 2.5, 3.0, 3.5 and 4.0 microg/ml resulted in the successful induction of anaesthesia in 13 (65 per cent), 16 (80 per cent), 20 (100 per cent) and 20 (100 per cent) of the dogs, respectively. The incidence of postinduction apnoea was 0 (0 per cent), one (5 per cent), two (10 per cent) and eight (40 per cent) at time 5 for groups 2.5, 3.0, 3.5 and 4.0 mug/ml, respectively, and its incidence at time 5 was significantly higher in the 4.0 microg/ml group (P<0.05) than in the other groups. In all the groups there was a significant (P<0.05) decrease in blood pressure between just before induction and the later measurements. Although there were no statistically significant differences between the groups in terms of inducing anaesthesia at a specific target, a target of 3.5 microg/ml appears to ensure a successful induction of anaesthesia without a significant increase in the incidence of apnoea.
G C Musk; D S J Pang; T Beths; D A Flaherty
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Veterinary record     Volume:  157     ISSN:  0042-4900     ISO Abbreviation:  Vet. Rec.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-03-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0031164     Medline TA:  Vet Rec     Country:  England    
Other Details:
Languages:  eng     Pagination:  766-70     Citation Subset:  IM    
Division of Companion Animal Sciences, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Bearsden, Glasgow G61 1QH, Scotland, UK.
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MeSH Terms
Anesthetics, Intravenous / blood,  pharmacokinetics*
Apnea / epidemiology,  veterinary*
Blood Pressure
Dog Diseases / epidemiology*
Dogs / physiology*
Dose-Response Relationship, Drug
Heart Rate / drug effects,  physiology
Propofol / blood,  pharmacokinetics*
Prospective Studies
Respiration / drug effects
Reg. No./Substance:
0/Anesthetics, Intravenous; 2078-54-8/Propofol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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