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Target biopsy using magnifying endoscopy in clinical management of gastric MALT lymphoma.
MedLine Citation:
PMID:  21443666     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background and aim: We have reported the characteristics of magnified endoscopic images of gastric MALT lymphoma before and after treatment. In this study, we investigated the diagnostic efficacy of magnified endoscopic images for target biopsy and evaluation of clinical remission. Patients and methods: Twenty-one patients diagnosed with localized gastric MALT lymphoma were enrolled. Magnified endoscopy was performed prior to treatment and at a mean period of 1.8 months (1-6 months)` after therapy (H. pylori eradication in 19 patients and radiation therapy in 2 patients). Microstructural pattern and abnormal vessels in the lesions were assessed, and corpus mucosa without lymphoma was divided into H. pylori-negative mucosa and H. pylori-positive mucosa. Biopsy was the gold standard in this study. Results: Nonstructural areas with abnormal vessels were observed in all patients before treatment. Fifteen patients achieved pathological complete remission. Disappearance of nonstructural areas and abnormal vessels after therapy was associated with pathological remission. Sensitivities of these findings for diagnosis were 76.9% and 85.7%, respectively, and the specificities were 87.5% and 85.7%, respectively. H. pylori eradication therapy was invalid in three patients with H. pylori-negative mucosa in magnified images. Conclusions: Magnifying endoscopy may be useful for target biopsy of superficial gastric MALT lymphoma in clinical management.
Authors:
Shouko Ono; Mototsugu Kato; Yuji Ono; Urara Nishida; Keiko Yamamoto; Yuichi Shimizu; Masahiro Asaka
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-28
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  -     ISSN:  1440-1746     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
Affiliation:
Division of Endoscopy, Hokkaido University Hospital, Sapporo Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
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