Document Detail

Tardive seizure and antibiotics: case reports and review of the literature.
MedLine Citation:
PMID:  18580694     Owner:  NLM     Status:  MEDLINE    
Tardive seizure is a serious adverse reaction of electroconvulsive therapy (ECT). However, it was rarely reported in ECT sessions for psychiatric patients who needed concurrent antibiotic treatments. We present 2 cases of patients with schizophrenia who manifested a catatonic syndrome and were indicated for ECT, along with antibiotic therapies for infectious diseases with piperacillin and cefotiam, respectively. The beta-lactam antibiotics are reported to induce convulsions caused by the suppression of inhibitory GABAergic functions. In addition, there is a report on prolonged ECT seizure related to ciprofloxacin, which has an epileptogenic property with a similar action to beta-lactam antibiotics. Thus, tardive seizures in our cases are thought to be related to piperacillin and cefotiam.
Takahiro Saito; Mitsuru Nakamura; Michiko Watari; Kunihiro Isse
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The journal of ECT     Volume:  24     ISSN:  1533-4112     ISO Abbreviation:  J ECT     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-05     Completed Date:  2009-03-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9808943     Medline TA:  J ECT     Country:  United States    
Other Details:
Languages:  eng     Pagination:  275-6     Citation Subset:  IM    
Department of Psychiatry, Tokyo Metropolitan Toshima Hospital, Tokyo, Japan.
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MeSH Terms
Anti-Bacterial Agents / adverse effects*
Antipsychotic Agents / therapeutic use
Electroconvulsive Therapy / adverse effects*
Middle Aged
Neuroleptic Malignant Syndrome / complications
Piperacillin / adverse effects,  therapeutic use
Pneumonia, Aspiration / drug therapy,  etiology
Risperidone / therapeutic use
Schizophrenia, Catatonic / drug therapy,  therapy
Schizophrenia, Paranoid / complications,  therapy
Seizures / chemically induced*,  etiology*
Urinary Tract Infections / complications,  drug therapy
Young Adult
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antipsychotic Agents; 106266-06-2/Risperidone; 61477-96-1/Piperacillin

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