Document Detail

Tardive dyskinesia in schizophrenia. Relationship to minor physical anomalies, frontal lobe dysfunction and cerebral structure on magnetic resonance imaging.
MedLine Citation:
PMID:  7551606     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It was hypothesised that schizophrenic patients with tardive dyskinesia show an excess of neurodevelopmental disturbance, particularly minor physical anomalies, in association with cognitive dysfunction and abnormalities of cerebral structure. METHOD: Forty-seven out-patients with a DSM-III diagnosis of schizophrenia were examined for tardive dyskinesia using the Abnormal Involuntary Movement Scale; they were examined also for minor physical anomalies and neuropsychological test performance. Cortical atrophy, signal hyperintensities and lateral ventricular volume were determined on magnetic resonance imaging. RESULTS: Patients with and without tardive dyskinesia could not be distinguished by age, gender distribution or a number of clinical measures; however, patients with tardive dyskinesia sorted fewer categories on the Wisconsin Card Sorting Test (P = 0.04). Cerebral structure in patients with and without tardive dyskinesia could not be distinguished on magnetic resonance imaging but those with dyskinesia, all of whom showed involvement of the orofacial region, showed more evident minor physical anomalies of the head relative to those of the periphery (P = 0.02). CONCLUSIONS: Tardive orofacial dyskinesia in schizophrenia appears to be associated particularly with poorer frontal lobe function, while predominance of craniofacial dysmorphogenesis may constitute a vulnerability factor that is related to the early origins of the disease process.
J L Waddington; E O'Callaghan; P Buckley; C Madigan; O Redmond; J P Stack; A Kinsella; C Larkin; J T Ennis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  167     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-11-21     Completed Date:  1995-11-21     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  41-4     Citation Subset:  IM    
Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin.
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MeSH Terms
Cerebral Cortex / abnormalities,  pathology*
Cerebral Ventricles / pathology*
Congenital Abnormalities / diagnosis*,  physiopathology
Delirium, Dementia, Amnestic, Cognitive Disorders / diagnosis,  psychology
Dyskinesia, Drug-Induced / diagnosis*,  physiopathology
Face / abnormalities
Frontal Lobe / pathology,  physiopathology*
Magnetic Resonance Imaging*
Middle Aged
Neuropsychological Tests*
Schizophrenia / diagnosis,  drug therapy*,  physiopathology
Schizophrenic Psychology*
Skull / abnormalities

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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