Document Detail

Tardive dyskinesia associated with depression in a bipolar patient: possible role of melatonin.
MedLine Citation:
PMID:  1979969     Owner:  NLM     Status:  MEDLINE    
Several clinical studies have suggested that patients with affective disorder are at high risk for developing tardive dyskinesia (TD). An intriguing aspect of the relationship between TD and affective disorders involves mood dependent alterations in the severity of TD in bipolar patients. In most reported cases, depressive episodes have been reported to be associated with exacerbation of TD, while manic episodes were accompanied by attenuation of TD. Current neurochemical hypotheses of TD do not explain adequately the relationship of TD to depression or mania in bipolar patients. A patient with bipolar illness is presented in whom TD emerged concurrently with the onset of depression that developed during management of an acute manic episode. It is suggested that decline in melatonin secretion with onset of the depression was associated with the emergence of TD. Thus, the increased incidence and risk of TD in bipolar patients may in part be related to decreased melatonin secretion, while increased melatonin secretion during manic episodes may have protective effect against the development of TD.
R Sandyk
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  52     ISSN:  0020-7454     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  1990 May 
Date Detail:
Created Date:  1991-02-13     Completed Date:  1991-02-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  79-83     Citation Subset:  IM    
Department of Psychiatry, College of Physicians & Surgeons, Columbia University, NY.
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MeSH Terms
Antipsychotic Agents / adverse effects,  therapeutic use
Bipolar Disorder / complications*,  drug therapy
Depression / complications*
Dyskinesia, Drug-Induced / complications*
Melatonin / physiology*
Reg. No./Substance:
0/Antipsychotic Agents; 73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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