Document Detail


DRD2/ANKK1 TaqI polymorphism and smoking behavior of Egyptian male cigarette smokers.
MedLine Citation:
PMID:  18058350     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Little is known about the genetic contribution to cigarette smoking and nicotine addiction in Egypt. The dopamine D2 receptor gene contains a TaqI repeat fragment length polymorphism creating two alleles with functional significance, DRD2*A1 and DRD2*A2. We investigated the relationship between these alleles and tobacco use in a study of 389 Egyptian male current smokers (mean age = 40 years; SD = 12). Participants were interviewed in 2004 on their smoking behaviors and quit attempts, and were given the Fagerström Test for Nicotine Dependence (FTND). Blood samples were obtained and genotyped for DRD2 A1and A2 alleles. The frequencies of A1/A2, A1/A2, and A2/A2 genotypes were 6%, 29%, and 65%, respectively. We found no statistically significant association between genotype and age at onset of smoking, years of smoking, FTND score, or average number of cigarettes smoked per day. DRD2 genotype was associated with the number of cigarettes smoked in the past 48 hr (42.2 in A1 carriers vs. 37.6 in A2, p = .03), the previous quit duration (28% in A1 vs. 40% in A2 quit for more than 1 month, p = .05), and the depth of inhalation (82% in A1 vs. 72% in A2 inhaled the smoke deeply, p = .03). Logistic regression analysis including DRD2 genotype, FTND score, age at smoking initiation, marital status, and education as predictors showed that maximum duration of quit time was associated with FTND score (p = .003), DRD2 genotype (p = .01), marital status (p = .03), and age at smoking initiation (p = .04). These findings suggest a modest association between DRD2 genotype and quitting behavior in male cigarette smokers in Egypt.
Authors:
Ghada N Radwan; Maged El-Setouhy; Mostafa K Mohamed; Mohamed Abdel Hamid; Salwa Abdel Azem; Omima Kamel; Ebenezer Israel; Christopher A Loffredo
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco     Volume:  9     ISSN:  1462-2203     ISO Abbreviation:  Nicotine Tob. Res.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-03-06     Revised Date:  2012-06-22    
Medline Journal Info:
Nlm Unique ID:  9815751     Medline TA:  Nicotine Tob Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1325-9     Citation Subset:  IM    
Affiliation:
Department of Public Health, Cairo University, Cairo, Egypt.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Behavior, Addictive / genetics
Egypt
Gene Frequency*
Humans
Male
Middle Aged
Polymorphism, Genetic*
Protein-Serine-Threonine Kinases / genetics*
Questionnaires
Receptors, Dopamine D2 / genetics*
Smoking / genetics*
Tobacco Use Disorder / genetics
Chemical
Reg. No./Substance:
0/Receptors, Dopamine D2; EC 2.7.11.1/ANKK1 protein, human; EC 2.7.11.1/Protein-Serine-Threonine Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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