| Tanshinone IIA in Acute Promyelocytic Leukemia. | |
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MedLine Citation:
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PMID: 22270391 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: The prognosis of acute promyelocytic leukemia (APL) has been significantly improved by the use of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). However, the utility of these drugs is limited by resistance to ATRA and the side effects of ATO. It has been reported that Tanshinone IIA (Tan IIA), a diterpene quinone isolated from Salvia Miltiorrhiza Bunge, induces apoptosis in the APL cell line, NB4. The effect of Tan IIA on the ATRA-resistant APL cell line (MR2) is unknown. METHODS: In this study, the effects of Tan IIA and ATO, alone and in combination, on MR2 cell apoptosis were investigated using transmission electron microscopy, flow cytometry and Western blot analyses. RESULTS: Nuclear changes typical of apoptosis were observed in Tan IIA-treated MR2 cells. Apoptosis was shown to be induced in a dose- and time-dependent manner with the activation of caspase-3 resulting in upregulation of tumor necrosis factor-α expression, activation of caspase-8 and alteration in mitochondrial transmembrane potential with release of cytochrome c (cyto-c). Tan IIA and ATO acted synergistically on the induction of MR2 cell apoptosis. CONCLUSIONS: These data indicate that Tan IIA may be beneficial in the treatment of ATRA-resistant APL and in combination with ATO for APL therapy in the clinic. |
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Authors:
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Jian Li; Kaiji Zhang; Wentong Meng; Yiming Yang |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-20 |
Journal Detail:
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Title: The American journal of the medical sciences Volume: - ISSN: 1538-2990 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Department of Hematology (JL, KZ, YY), West China Medical School and Laboratory of Stem Cell Biology (WM), State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan Province, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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