Document Detail

Tannic acid incorporation in chitosan-based microparticles and in vitro controlled release.
MedLine Citation:
PMID:  19160025     Owner:  NLM     Status:  MEDLINE    
Chitosan, a natural polycationic polysaccharide, was coupled with two polyanionic polymers: Na-alginate and carboxymethylcellulose (CMC) and with tannic acid (TA) obtaining three species of self-assembled complexes: chitosan/alginate/TA (sample 1), chitosan/TA (sample 2) and chitosan/CMC/TA (sample 3). The microparticle formation was achieved by dropwise addition of one solution into other by using a coaxial airflow sprayer. These systems were characterized with regard to particle size distribution, thermal stability, tannic acid entrapment efficiency. Sample 2 showed quite a different behavior compared to the other two samples; the particle diameter is located in the nanometric region, the quantity of incorporated tannic acid is higher than in the other two samples and the material shows better thermal stability. The release of tannic acid from these complexes was studied in water (pH = 5.89), phosphates buffer (pH = 7.04) and acetate buffer (pH = 4.11). These studies revealed two distinct periods in tannic acid delivery process: an initial period, varying between 4 and 10 h, characterized by a high release rate with a delivered tannic acid amount of approximately 80% of the incorporated polyphenol and a second period, which starts after 20 to 30 h of delivery and it ends after approximately 120 h, when the release process takes place with low and constant rate and the kinetic curve is linear--characteristic for a zero order kinetic.
Neculai Aelenei; Marcel Ionel Popa; Ovidiu Novac; Gabriela Lisa; Lacramioara Balaita
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-22
Journal Detail:
Title:  Journal of materials science. Materials in medicine     Volume:  20     ISSN:  1573-4838     ISO Abbreviation:  J Mater Sci Mater Med     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-01     Completed Date:  2009-07-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013087     Medline TA:  J Mater Sci Mater Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1095-102     Citation Subset:  IM    
Chemical Engineering Department, Chemical Engineering and Environment Protection Faculty, Technical University of Iasi, Iasi, Romania.
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MeSH Terms
Alginates / chemistry
Biocompatible Materials / chemistry*
Chitosan / chemistry*
Delayed-Action Preparations
Drug Carriers / chemistry*
Glucuronic Acid / chemistry
Hexuronic Acids / chemistry
Hydrogen-Ion Concentration
Materials Testing
Particle Size
Spectroscopy, Fourier Transform Infrared
Tannins / administration & dosage*
Reg. No./Substance:
0/Alginates; 0/Biocompatible Materials; 0/Delayed-Action Preparations; 0/Drug Carriers; 0/Hexuronic Acids; 0/Tannins; 576-37-4/Glucuronic Acid; 9005-32-7/alginic acid; 9012-76-4/Chitosan

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