| A Tannic Acid-Based Medical Food, Cesinex(®), Exhibits Broad-Spectrum Antidiarrheal Properties: A Mechanistic and Clinical Study. | |
| | |
MedLine Citation:
|
PMID: 21748285 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: The purpose of this investigation was to evaluate the efficacy and tolerability of a tannic acid-based medical food, Cesinex(®), in the treatment of diarrhea and to investigate the mechanisms underlying its antidiarrheal effect. METHODS: Cesinex(®) was prescribed to six children and four adults with diarrhea. Patient records were retrospectively reviewed for the primary outcome. Cesinex(®) and its major component, tannic acid, were tested for their effects on cholera toxin-induced intestinal fluid secretion in mice. Polarized human gut epithelial cells (HT29-CL19A cells) were used to investigate the effects of tannic acid on epithelial barrier properties, transepithelial chloride secretion, and cell viability. RESULTS: Successful resolution of diarrheal symptoms was reported in nine of ten patients receiving Cesinex(®). The treatment of HT29-CL19A cells with clinically relevant concentrations of tannic acid (0.01-1 mg/ml) significantly increased transepithelial resistance (TER) and inhibited the cystic fibrosis transmembrane conductance regulator (CFTR)-dependent or the calcium-activated Cl(-) secretion. Tannic acid could also improve the impaired epithelial barrier function induced by tumor necrosis factor alpha (TNFα) and inhibited the disrupting effect of TNFα on the epithelial barrier function in these cells. Cholera toxin (CTX)-induced mouse intestinal fluid secretion was significantly reduced by the administration of Cesinex(®) or tannic acid. Cesinex(®) has high antioxidant capacity. CONCLUSIONS: Cesinex(®) demonstrates efficacy and a good safety profile in the treatment of diarrhea. The broad-spectrum antidiarrheal effect of Cesinex(®) can be attributed to a combination of factors: its ability to improve the epithelial barrier properties, to inhibit intestinal fluid secretion, and the high antioxidant capacity. |
| | |
Authors:
|
Aixia Ren; Weiqiang Zhang; Hugh Greg Thomas; Amy Barish; Stephen Berry; Jeffrey S Kiel; Anjaparavanda P Naren |
Related Documents
:
|
17022015 - Online acid barrage stacking anti-salt injection for capillary electrophoresis of 9-flu... 16837005 - Separation and determination of perfluorinated carboxylic acids using capillary zone el... 2171855 - Three different methods of inhibiting lipolysis in human chyme in vitro: efficiency and... 15797805 - Simultaneous determination of gallic acid, albiflorin, paeoniflorin, ferulic acid and b... 16339155 - A major cell wall lipopeptide of mycobacterium avium subspecies paratuberculosis. 1492755 - N-3 polyunsaturated fatty acid supplementation (pikasol) in men with moderate and sever... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-12 |
Journal Detail:
|
Title: Digestive diseases and sciences Volume: - ISSN: 1573-2568 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, 415 Nash Research Building, Memphis, TN, 38163, USA, aren@uthsc.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A Failure to Normalize Biochemical and Metabolic Insults During Morphine Withdrawal Disrupts Synapti...
Next Document: Increase in the Tight Junction Protein Claudin-1 in Intestinal Inflammation.