| Tanikolide, a toxic and antifungal lactone from the marine cyanobacterium Lyngbya majuscula. | |
| | |
MedLine Citation:
|
PMID: 10514329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A new brine-shrimp toxic and antifungal compound, tanikolide 1, has been isolated from the lipid extract of a Madagascan collection of the marine cyanobacterium Lyngbya majuscula. The structure of tanikolide was determined by spectroscopic methods, relying heavily on 2D NMR spectroscopy. The absolute configuration at C-5 of tanikolide was established as R by oxidizing the primary alcohol to an acid and analyzing the corresponding (R)- and (S)-PGME amide derivatives by (1)H NMR. |
| | |
Authors:
|
I P Singh; K E Milligan; W H Gerwick |
Related Documents
:
|
23596559 - Empiric mathematical model for predicting the content of alpha-acids in hop (humulus lu... 23109829 - Graphene nanoplatelets as novel reinforcement filler in poly(lactic acid)/epoxidized pa... 16531229 - Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex ... 23069609 - Physicochemical properties of bio-oil and biochar produced by fast pyrolysis of stored ... 3125789 - Revised structure for the phenazine antibiotic from pseudomonas fluorescens 2-79 (nrrl ... 10857059 - Synthesis, circular dichroism, and absolute stereochemistry of a fecht acid analog and ... 6789289 - A simple routine method for mono and diamine oxidase estimation in human serum. 7970149 - Extreme stability of tyr-mif-1 in csf. 16806629 - Cyclic fatty acid monomer formation in domestic frying of frozen foods in sunflower oil... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of natural products Volume: 62 ISSN: 0163-3864 ISO Abbreviation: J. Nat. Prod. Publication Date: 1999 Sep |
Date Detail:
|
Created Date: 1999-11-22 Completed Date: 1999-11-22 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1333-5 Citation Subset: IM |
Affiliation:
|
College of Pharmacy, Oregon State University, Corvallis, Oregon, 97331-3507, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antifungal Agents / chemistry, isolation & purification*, pharmacology Bacteria / drug effects Candida albicans / drug effects Cyanobacteria / isolation & purification* Decapoda (Crustacea) / drug effects Goldfish Lactones / chemistry, isolation & purification*, pharmacology Microbial Sensitivity Tests Molecular Structure Mollusca / drug effects Spectrum Analysis |
| Grant Support | |
ID/Acronym/Agency:
|
CA52955/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antifungal Agents; 0/Lactones; 0/tanikolide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: New nitrogenous bisabolene-type sesquiterpenes from a micronesian marine sponge, axinyssa species
Next Document: New antimycobacterial saponin from Colubrina retusa.