Document Detail


Tanikolide, a toxic and antifungal lactone from the marine cyanobacterium Lyngbya majuscula.
MedLine Citation:
PMID:  10514329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new brine-shrimp toxic and antifungal compound, tanikolide 1, has been isolated from the lipid extract of a Madagascan collection of the marine cyanobacterium Lyngbya majuscula. The structure of tanikolide was determined by spectroscopic methods, relying heavily on 2D NMR spectroscopy. The absolute configuration at C-5 of tanikolide was established as R by oxidizing the primary alcohol to an acid and analyzing the corresponding (R)- and (S)-PGME amide derivatives by (1)H NMR.
Authors:
I P Singh; K E Milligan; W H Gerwick
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of natural products     Volume:  62     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-22     Completed Date:  1999-11-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1333-5     Citation Subset:  IM    
Affiliation:
College of Pharmacy, Oregon State University, Corvallis, Oregon, 97331-3507, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antifungal Agents / chemistry,  isolation & purification*,  pharmacology
Bacteria / drug effects
Candida albicans / drug effects
Cyanobacteria / isolation & purification*
Decapoda (Crustacea) / drug effects
Goldfish
Lactones / chemistry,  isolation & purification*,  pharmacology
Microbial Sensitivity Tests
Molecular Structure
Mollusca / drug effects
Spectrum Analysis
Grant Support
ID/Acronym/Agency:
CA52955/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Lactones; 0/tanikolide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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