Document Detail


Tanghinigenin from seeds of Cerbera manghas L. induces apoptosis in human promyelocytic leukemia HL-60 cells.
MedLine Citation:
PMID:  21787626     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Tanghinigenin, a cardiac glycoside, is isolated from the seeds of Cerbera manghas L. In this study, we demonstrated that tanghinigenin reduced the viability of human promyelocytic leukemia HL-60 cells in a time- and dose-dependent manner, and efficiently induced apoptosis in HL-60 cells as evidenced by the Annexin V/PI binding assay, DNA fragmentation and AO/EB staining studies. In addition, stimulation of HL-60 cells with tanghinigenin induced a series of intracellular events including the activation of caspase-3, -8, and -9, as well as up-regulation of Fas and FasL protein level. Taken together, caspase activation and Fas/FasL interaction was found to be involved in tanghinigenin-induced HL-60 cell apoptosis.
Authors:
Guo-Fei Wang; Yue-Wei Guo; Bo Feng; Liang Li; Cai-Guo Huang; Bing-Hua Jiao
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Publication Detail:
Type:  Journal Article     Date:  2010-03-17
Journal Detail:
Title:  Environmental toxicology and pharmacology     Volume:  30     ISSN:  1872-7077     ISO Abbreviation:  Environ. Toxicol. Pharmacol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2011-07-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612020     Medline TA:  Environ Toxicol Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  31-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Biochemistry and Molecular Biology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People's Republic of China.
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