Document Detail

Tandemly arranged gene clusters of malarial parasites that are highly conserved and transcribed.
MedLine Citation:
PMID:  3033497     Owner:  NLM     Status:  MEDLINE    
A molecular clone containing a 5.8 kb Eco RI fragment was isolated from a genomic library of the rodent malarial parasite Plasmodium yoelii. The P. yoelii genome contains about 150 copies of this sequence, making up almost 3% of the DNA. These sequences are tandemly arrayed in head-to-tail configurations with the unit length of the repeat being 5.8 kb. Several poly(A+) RNAs of P. yoelii ranging from 1.6 to 0.3 kb are recognized by the 5.8 kb clone. Five additional species of malarial parasites (P. chabaudi, P. berghei, P. falciparum, P. knowlesi, and P. cynomolgi) contain tandemly repeated arrays of sequences having the same unit length of 5.8 kb, which readily hybridize to the sequence cloned from P. yoelii.
A B Vaidya; P Arasu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Molecular and biochemical parasitology     Volume:  22     ISSN:  0166-6851     ISO Abbreviation:  Mol. Biochem. Parasitol.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-05-26     Completed Date:  1987-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006324     Medline TA:  Mol Biochem Parasitol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  249-57     Citation Subset:  IM    
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MeSH Terms
Cloning, Molecular
DNA / analysis*,  genetics
DNA Restriction Enzymes
Deoxyribonuclease EcoRI
Electrophoresis, Agar Gel
Nucleic Acid Hybridization
Plasmodium / genetics*
Plasmodium berghei / genetics
Plasmodium falciparum / genetics
Protein Biosynthesis
Repetitive Sequences, Nucleic Acid
Transcription, Genetic
Reg. No./Substance:
9007-49-2/DNA; EC 3.1.21.-/DNA Restriction Enzymes; EC 3.1.21.-/Deoxyribonuclease EcoRI

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