Document Detail


Tandem adaptation with a common design in Escherichia coli chemotaxis.
MedLine Citation:
PMID:  22922485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We analyze a model for motor-level adaptation in Escherichia coli based upon the premise that clockwise (CW) and counter-clockwise (CCW) states have different preferred numbers of FliM subunits. We show that this model provides a simple mechanism for the recently observed motor-level adaptation, and it also explains the long-lasting puzzle on the thresholds observed when tethered cells are used to monitor responses to temporal ramps. We note that the motor-level adaptation has the same negative-feedback network design as the upstream receptor-level adaptation, and the tandem architecture of one control circuit followed by the other mitigates the effects of cell-to-cell variation and broadens the range of stimuli over which cells optimally respond.
Authors:
Yuhai Tu; Howard C Berg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-08-24
Journal Detail:
Title:  Journal of molecular biology     Volume:  423     ISSN:  1089-8638     ISO Abbreviation:  J. Mol. Biol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-15     Completed Date:  2012-12-31     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  2985088R     Medline TA:  J Mol Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  782-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
IBM T. J. Watson Research Center, 1101 Kitchwan Rd., Yorktown Heights, NY 10598, USA. Electronic address: yuhai@us.ibm.com.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological*
Chemotaxis*
Escherichia coli / physiology*
Flagella / physiology
Grant Support
ID/Acronym/Agency:
AI016478/AI/NIAID NIH HHS; GM081747/GM/NIGMS NIH HHS; R01 AI016478/AI/NIAID NIH HHS; R01 GM081747/GM/NIGMS NIH HHS
Comments/Corrections

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