| A tandem catalytic approach to methyleneindenes: mechanistic insights into gem-dibromoolefin reactivity. | |
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MedLine Citation:
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PMID: 20486725 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The methylenindene scaffold can be prepared from readily available gem-dibromoolefins using an efficient palladium-catalyzed tandem intermolecular Suzuki/intramolecular Heck reaction. The reaction is highly modular and proceeds under mild conditions. The choice of ligand was found to be crucial to control the selectivity of the reaction. Isolation of intermediates under different conditions provides insight into the mechanism. |
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Authors:
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Christopher S Bryan; Mark Lautens |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Organic letters Volume: 12 ISSN: 1523-7052 ISO Abbreviation: Org. Lett. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-11 Completed Date: 2010-09-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: United States |
Other Details:
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Languages: eng Pagination: 2754-7 Citation Subset: IM |
Affiliation:
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Davenport Laboratories, Department of Chemistry, University of Toronto, Toronto, Ontario, Canada M5S 3H6. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alkenes
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chemistry* Catalysis Hydrocarbons, Brominated / chemistry* Indenes / chemical synthesis*, chemistry Molecular Structure Palladium / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Alkenes; 0/Hydrocarbons, Brominated; 0/Indenes; 7440-05-3/Palladium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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