Document Detail


Tandem Catalysis for the Preparation of Cylindrical Polypeptide Brushes.
MedLine Citation:
PMID:  23134537     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Here, we report a method for synthesis of cylindrical copolypeptide brushes via N-carboxyanhydride polymerization utilizing a new tandem catalysis approach that allows preparation of brushes with controlled segment lengths in a straightforward, one-pot procedure requiring no intermediate isolation or purification steps. To obtain high density brush copolypeptides, we used a "grafting from" approach where alloc-α-aminoamide groups were installed onto the side-chains of N-carboxyanhydrides to serve as masked initiators. These groups were inert during cobalt initiated N-carboxyanhydride polymerization, and gave allyloxycarbonyl-α-aminoamide substituted polypeptide main-chains. The alloc-α-aminoamide groups were then activated in situ using nickel to generate initiators for growth of side-chain brush segments. This use of stepwise tandem cobalt and nickel catalysis was found to be an efficient method for preparation of high chain density, cylindrical copolypeptide brushes, where both the main-chains and side-chains can be prepared with controlled segment lengths.
Authors:
Allison J Rhodes; Timothy J Deming
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-8
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  -     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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