Document Detail


Tamoxifen produces conditioned taste avoidance in male rats: an analysis of microstructural licking patterns and taste reactivity.
MedLine Citation:
PMID:  19576896     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Estrogen receptor activation has been shown to reduce body weight and produce a conditioned reduction in food intake in male rats that is putatively mediated by estradiol's suggested aversive effects. Evidence has shown that the selective estrogen receptor modulator tamoxifen used in the prevention and treatment of breast cancer may also produce changes in food intake and body weight, which are known to impact cancer development and survival. The purpose of the present study was to examine whether tamoxifen produces a conditioned reduction in intake similar to estradiol by producing a conditioned aversion. A one bottle lickometer test was used to examine conditioned changes in sucrose drinking, while the taste reactivity test was used to measure rejection reactions, which serve to index aversion in rats. A backward conditioning procedure that consisted of 3 conditioning days and one vehicle test day was used to examine conditioned changes in 0.3 M sucrose intake and taste reactivity. Our results show that tamoxifen produced a conditioned reduction in sucrose drinking in a one bottle fluid intake test that was similar to the effects produced by estradiol (positive control); however, no active rejection reactions were produced by either tamoxifen (1 and 10 mg/kg) or estradiol. The present results suggest that tamoxifen, at the doses used in the present study, acts as an estrogen receptor agonist to regulate food intake and that the conditioned reduction in intake produced by tamoxifen and estradiol reflects conditioned taste avoidance rather than conditioned taste aversion.
Authors:
Melissa A Fudge; Martin Kavaliers; John-Paul Baird; Klaus-Peter Ossenkopp
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-07-02
Journal Detail:
Title:  Hormones and behavior     Volume:  56     ISSN:  1095-6867     ISO Abbreviation:  Horm Behav     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-07     Completed Date:  2009-11-04     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  0217764     Medline TA:  Horm Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  322-31     Citation Subset:  IM    
Affiliation:
Department of Psychology, The University of Western Ontario, London, Ontario, Canada. melissa.fudge@queensu.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Avoidance Learning / drug effects*
Body Weight
Conditioning, Classical / drug effects*
Drinking Behavior / drug effects*
Estradiol / pharmacology
Estrogens / pharmacology
Locomotion / drug effects
Male
Motor Activity / drug effects
Rats
Rats, Long-Evans
Selective Estrogen Receptor Modulators / administration & dosage,  pharmacology*
Sucrose / administration & dosage
Tamoxifen / administration & dosage,  pharmacology*
Taste / drug effects
Time Factors
Grant Support
ID/Acronym/Agency:
DC-07389/DC/NIDCD NIH HHS; R15 DC007389-02/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Estrogens; 0/Selective Estrogen Receptor Modulators; 10540-29-1/Tamoxifen; 50-28-2/Estradiol; 57-50-1/Sucrose
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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