Document Detail

Tamoxifen and gallstone formation in postmenopausal breast cancer patients: retrospective cohort study.
MedLine Citation:
PMID:  12658480     Owner:  NLM     Status:  MEDLINE    
Tamoxifen is being used successfully in breast cancer patients as adjuvant hormonal therapy. The aim of this retrospective cohort study is to evaluate the impact of tamoxifen on gallstone formation in postmenopausal breast cancer patients. A total of 3165 patients who were treated for invasive breast cancer between 1990 and 1997 were reviewed. The data were collected from four university hospitals in a population-based registry. Among these patients, 2462 were excluded from the study owing to improper follow-up and other reasons. Premenopausal patients were also excluded. Of the 703 patients included in the study, 457 had received adjuvant therapy including tamoxifen, and the other 246 had not. Gallstone formation was assessed by annual abdominal ultrasonography. The mean follow-up period was 4.6 years (range 1-7 years). There were no significant differences between the groups of breast cancer patients treated with or without tamoxifen regarding the age of the patients at the time of breast cancer diagnosis, the age at menopause, the duration between the onset of menopause and the time the breast cancer was diagnosed, the presence of diabetes, and the body mass index. At the end of 5 years the incidence of gallstone formation in tamoxifen-treated patients was 37.4%, whereas it was 2.0% in patients who did not receive tamoxifen ( p < 0.0001). The incidences of gallstones being detected in 171 tamoxifen-treated patients were 0.4%, 3.7%, 24.4%, 33.1%, and 37.4% cumulatively during the first, second, third, fourth, and fifth years, respectively. Hence adjuvant tamoxifen therapy leads to gallstone formation in postmenopausal breast cancer patients and is most apparent after 3 years of treatment.
Mehmet L Akin; Haldun Uluutku; Cengiz Erenoglu; Ahmet Karadag; Bahadir M Gulluoglu; Burak Sakar; Tuncay Celenk
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of surgery     Volume:  27     ISSN:  0364-2313     ISO Abbreviation:  World J Surg     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-03-26     Completed Date:  2003-09-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7704052     Medline TA:  World J Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  395-9     Citation Subset:  IM    
Department of Surgery, Gulhane Military Medical Academy, Haydarpasa Teaching Hospital, Tibbiye Caddesi, Kadikoy, 81327 Istanbul, Turkey.
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MeSH Terms
Aged, 80 and over
Breast Neoplasms / drug therapy*,  surgery
Cholelithiasis / chemically induced*,  ultrasonography
Cohort Studies
Estrogen Receptor Modulators / adverse effects*
Middle Aged
Retrospective Studies
Tamoxifen / adverse effects*
Reg. No./Substance:
0/Estrogen Receptor Modulators; 10540-29-1/Tamoxifen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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