| "Tall oil"-derived phytosterols reduce atherosclerosis in ApoE-deficient mice. | |
| | |
MedLine Citation:
|
PMID: 9012646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We investigated the effects of a "tall oil"-derived phytosterol mixture (TODPM) on the formation of atherosclerotic lesions in apoE-deficient mice. TODPM was added at 2% (wt/wt) to the chow of nine mice; the control group had six animals. The diet of all animals contained 9% (wt/wt) fat and 0.15% (wt/wt) cholesterol. After 4 weeks, plasma total cholesterol levels were significantly reduced in the TODPM-treated mice (26.6 versus 42.0 mmol/L, P < .0001). The mean body weight of the TODPM-supplemented group was significantly higher at week 5 and throughout the study (29.4 versus 27.7 g, P < .05). The experiment was terminated at 18 weeks. Histological examination showed mature atherosclerotic lesions composed of foam cells underlying the endothelium, a mosaic of extracellular glycosaminoglycans, numerous apparently proliferative smooth muscle cells, and foci of cholesterol clefts in the control animals. By contrast, the TODPM-treated mice showed only early lesions containing mainly superficial foam cells. As assessed by morphometry, the lesion area in the aortic sinuses of TODPM-treated animals was less than half that of control animals (P < .0001). This reduced lesion area was accompanied by a substantial reduction in all lesional components, reflecting a delay in progression of atheromatous changes. A strong positive correlation (r = .69, P < .01) was found between plasma total cholesterol levels and lesion area in the aortic sinuses. TODPM also prevented the occurrence of xanthomatosis. We conclude that supplementation of a cholesterol-enriched diet with TODPM significantly lowers plasma cholesterol and retards development of atherosclerosis in apoE-deficient mice, suggesting a therapeutic potential for the mixture of phytosterols studied. |
| | |
Authors:
|
M H Moghadasian; B M McManus; P H Pritchard; J J Frohlich |
Related Documents
:
|
9089806 - Dietary deficiency or enrichment of essential fatty acids modulates tumorigenesis in th... 8951166 - Restorative effect of shosaikoto (kampo medicine) on diminution of nitric oxide synthes... 20219986 - Development of high-fat-diet-induced obesity in female metallothionein-null mice. 20864666 - Effect of early particulate air pollution exposure on obesity in mice: role of p47phox. 2756026 - The effect of increased adiposity on food intake of juvenile rats. 7282936 - Uptake of cholesterol into rabbit jejunum using three in vitro techniques: importance o... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 17 ISSN: 1079-5642 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 1997 Jan |
Date Detail:
|
Created Date: 1997-02-25 Completed Date: 1997-02-25 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 119-26 Citation Subset: IM |
Affiliation:
|
Healthy Heart Program, St. Paul's Hospital, Vancouver, Canada. jifr@unixg.ubc.ca |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aorta / drug effects, pathology Apolipoproteins E / deficiency* Arteriosclerosis / drug therapy*, metabolism Male Mice Mice, Inbred C57BL Mice, Mutant Strains Phytosterols / administration & dosage* |
| Chemical | |
Reg. No./Substance:
|
0/Apolipoproteins E; 0/Phytosterols |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Plasma protein C inhibitor is elevated in survivors of myocardial infarction.
Next Document: The redox status of coenzyme Q10 in total LDL as an indicator of in vivo oxidative modification. Stu...