| Talin 2 concentrations in cerebrospinal fluid in patients with epilepsy. | |
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MedLine Citation:
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PMID: 20620133 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Talin 2 plays an important role in cell adhesion and recycling of synaptic vesicles. To explore the possible role of talin 2 in epilepsy, we designed current study to quantitatively evaluate the changes in talin 2 levels in different epilepsy patients. DESIGN AND METHODS: We measured talin 2 levels in CSF and the serum of postencephalitic epilepsy (PEE) patients (subdivided into drug-refractory PEE-RPEE, and drug-effective PEE-EPEE groups) and acute encephalitis patients (subdivided into acute encephalitis with secondary seizures-AESS, and acute encephalitis without seizures-AE) by enzyme-linked immunosorbent assay. RESULTS: We found that, in RPEE patients, interictal CSF-talin 2 concentrations significantly increased, whereas serum-talin 2 significantly decreased when compared with the AE, AESS, and EPEE groups. CONCLUSIONS: This result suggested that the differential concentration of CSF and serum-talin 2 in the RPEE group is an intractability-related phenomenon that might be involved in the development of RPEE. |
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Authors:
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Zheng Xiao; Lan Shen; Dan Chen; Liang Wang; Zhiqin Xi; Fei Xiao; Xuefeng Wang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-08 |
Journal Detail:
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Title: Clinical biochemistry Volume: 43 ISSN: 1873-2933 ISO Abbreviation: Clin. Biochem. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-31 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 1129-32 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, 1 You Yi Road, Chongqing 400016, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Drug Resistance Encephalitis / cerebrospinal fluid Epilepsy / cerebrospinal fluid* Female Humans Male Middle Aged Seizures / cerebrospinal fluid Talin / blood, cerebrospinal fluid* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/TLN2 protein, human; 0/Talin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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