Document Detail

Takotsubo cardiomyopathy: pathogenetic insights and myocardial perfusion kinetics using myocardial contrast echocardiography.
MedLine Citation:
PMID:  18579499     Owner:  NLM     Status:  MEDLINE    
Transient apical ballooning syndrome or Takotsubo cardiomyopathy (TC) is a novel acute cardiac syndrome, characterized by regional systolic dysfunction involving the apex and mid-ventricular segments, with hyperkinesis of the basal segments. Mid-ventricular ballooning cardiomyopathy (MVBC) is a recently recognized variant of TC. Both disorders share the same precipitating factors, clinical features and course; however, unlike TC, MVBC is characterized by ballooning and akinesis of the mid-ventricular segments with hypercontractility of the basal and apical segments. While the precise pathogenetic mechanism of this disorder remains elusive, microvascular dysfunction from excessive catecholamine release has been implicated. We report findings on regional contractile dysfunction (strain imaging), myocardial blood flow (semi-quantitative), and perfusion kinetics using myocardial contrast echocardiography in a series of three illustrative cases of TC.
Luis Afonso; Khaled Bachour; Khaled Awad; Greg Sandidge
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-06-20
Journal Detail:
Title:  European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology     Volume:  9     ISSN:  1532-2114     ISO Abbreviation:  Eur J Echocardiogr     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-24     Completed Date:  2009-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890618     Medline TA:  Eur J Echocardiogr     Country:  England    
Other Details:
Languages:  eng     Pagination:  849-54     Citation Subset:  IM    
Division of Cardiology, 3990 John R, 8 Brush, Harper University Hospital, Wayne State University, Detroit Medical Center, Detroit, MI 48201, USA.
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MeSH Terms
Coronary Circulation*
Diagnosis, Differential
Fluorocarbons / diagnostic use
Middle Aged
Takotsubo Cardiomyopathy / etiology,  ultrasonography*
Reg. No./Substance:
0/Definity; 0/Fluorocarbons

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