Document Detail

Takotsubo cardiomyopathy associated with titration of duloxetine.
MedLine Citation:
PMID:  22163139     Owner:  NLM     Status:  MEDLINE    
Takotsubo cardiomyopathy is characterized by transient multisegmental left ventricular dysfunction, dynamic electrocardiographic changes that mimic acute myocardial infarction, and the absence of obstructive coronary disease. Takotsubo cardiomyopathy has been solidly associated with antecedent emotional and physical stressors that trigger catecholamine surges, which lead to coronary vasospasm or direct myocardial injury. Some medications can also cause catecholamine surges, although this phenomenon is not as well described. Duloxetine is a combined serotonin and norepinephrine reuptake inhibitor (SNRI). The basic goal of SNRIs is to increase catecholamine levels in neuronal tissue. However, the increased catecholamine levels may also affect the cardiovascular system.Herein, we report the case of a 59-year-old woman whose takotsubo cardiomyopathy was temporally associated with the titration of duloxetine. The duloxetine therapy was subsequently discontinued, and the patient's left ventricular function recovered completely 1 month after the index event. The purpose of this report is to alert clinicians to a possible association between SNRI medications and takotsubo cardiomyopathy.
Kristopher J Selke; Gaurav Dhar; Joel M Cohn
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital     Volume:  38     ISSN:  1526-6702     ISO Abbreviation:  Tex Heart Inst J     Publication Date:  2011  
Date Detail:
Created Date:  2011-12-14     Completed Date:  2012-11-13     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  8214622     Medline TA:  Tex Heart Inst J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  573-6     Citation Subset:  IM    
Department of Cardiovascular Medicine, Ingham Regional Medical Center/Michigan State University, Lansing, Michigan 48910, USA.
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MeSH Terms
Adrenergic Uptake Inhibitors / adverse effects*
Antidepressive Agents / adverse effects*
Coronary Angiography
Middle Aged
Recovery of Function
Serotonin Uptake Inhibitors / adverse effects*
Stroke Volume / drug effects
Takotsubo Cardiomyopathy / chemically induced*,  diagnosis,  physiopathology,  therapy
Thiophenes / adverse effects*
Treatment Outcome
Ventricular Function, Left / drug effects
Reg. No./Substance:
0/Adrenergic Uptake Inhibitors; 0/Antidepressive Agents; 0/Serotonin Uptake Inhibitors; 0/Thiophenes; O5TNM5N07U/duloxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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