Document Detail

Takotsubo cardiomyopathy: Pathophysiology, diagnosis and treatment.
MedLine Citation:
PMID:  25068020     Owner:  NLM     Status:  PubMed-not-MEDLINE    
In 1990, takotsubo cardiomyopathy (TCM) was first discovered and reported by a Japanese cardiovascular specialist. Since then, this heart disease has gained worldwide acceptance as an independent disease entity. TCM is an important entity that differs from acute myocardial infarction. It occurs more often in postmenopausal elderly women, is characterized by a transient hypokinesis of the left ventricular (LV) apex, and is associated with emotional or physical stress. Wall motion abnormality of the LV apex is generally transient and resolves within a few days to several weeks. Its prognosis is generally good. However, there are some reports of serious TCM complications, including hypotension, heart failure, ventricular rupture, thrombosis involving the LV apex, and torsade de pointes. It has been suggested that coronary spasm, coronary microvascular dysfunction, catecholamine toxicity and myocarditis might contribute to the pathogenesis of TCM. However, its pathophysiology is not clearly understood.
Kazuo Komamura; Miho Fukui; Toshihiro Iwasaku; Shinichi Hirotani; Tohru Masuyama
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  World journal of cardiology     Volume:  6     ISSN:  1949-8462     ISO Abbreviation:  World J Cardiol     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-07-28     Completed Date:  2014-07-28     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101537090     Medline TA:  World J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  602-9     Citation Subset:  -    
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