Document Detail

Tako-tsubo cardiomyopathy in a patient with bilateral lesions in the dorsal medulla.
MedLine Citation:
PMID:  20963467     Owner:  NLM     Status:  MEDLINE    
Tako-tsubo-like cardiomyopathy (TTC) is much more common than originally thought. The exact pathophysiology of TTC is unclear. The most accepted theory proposes myocardial stunning of neurogenic origin, supported by the frequent antecedent of emotional or physical stress, suggesting a catecholamine-mediated mechanism. We present a patient with this syndrome and bilateral damage of the dorsal medulla oblongata likely affecting both solitary tract nuclei. Our case points to a link between baroreflex failure and TTC, highlighting the important role of sympathetic discharge in the pathophysiology of TTC.
Koldo Berganzo; Roberto Ciordia; Juan C Gómez-Esteban; Beatriz Tijero; Marta Agundez; Fernando Velasco; Maria A Valle; Juan J Zarranz
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-10-21
Journal Detail:
Title:  Clinical autonomic research : official journal of the Clinical Autonomic Research Society     Volume:  21     ISSN:  1619-1560     ISO Abbreviation:  Clin. Auton. Res.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-02     Completed Date:  2011-05-19     Revised Date:  2012-07-17    
Medline Journal Info:
Nlm Unique ID:  9106549     Medline TA:  Clin Auton Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  65-7     Citation Subset:  IM    
Department of Neurology, Hospital Cruces, Plaza de Cruces s/n, Baracaldo, Vizcaya, Spain.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use
Blood Pressure / physiology
Bradycardia / complications,  physiopathology
Brain / pathology
Coronary Angiography
Dizziness / etiology
Inflammation / pathology
Jogging / physiology
Magnetic Resonance Imaging
Medulla Oblongata / pathology*
Methylprednisolone / therapeutic use
Myocardial Stunning
Pneumonia, Mycoplasma / complications,  physiopathology
Spinal Cord / pathology
Takotsubo Cardiomyopathy / drug therapy,  etiology*,  physiopathology*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 83-43-2/Methylprednisolone
Comment In:
Clin Auton Res. 2011 Feb;21(1):1-2   [PMID:  21240537 ]
Auton Neurosci. 2012 Jul 2;169(1):4-6   [PMID:  22579400 ]

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