Document Detail


Taking angiotensin-converting enzyme inhibitors during pregnancy: is it safe?
MedLine Citation:
PMID:  22267620     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
QUESTION: One of my 35-year-old pregnant patients has been treated with enalapril for primary hypertension. She learned she was pregnant at 11 weeks' gestation. I read somewhere that angiotensin-converting enzyme (ACE) inhibitors can cause malformations. What advice do you give to Motherisk callers?
ANSWER: Most published studies have failed to show an effect of ACE inhibitors on congenital malformations. A recent systematic review and meta-analysis conducted by Motherisk does not suggest increased fetal risk of malformations. However, ACE inhibitors should be avoided in late pregnancy, as they might cause renal failure and acalvaria in the baby.
Authors:
Almundher Al-Maawali; Asnat Walfisch; Gideon Koren
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian family physician Médecin de famille canadien     Volume:  58     ISSN:  1715-5258     ISO Abbreviation:  Can Fam Physician     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-23     Completed Date:  2012-08-16     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0120300     Medline TA:  Can Fam Physician     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  49-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Angiotensin-Converting Enzyme Inhibitors / adverse effects*
Antihypertensive Agents / adverse effects*
Congenital Abnormalities / etiology*
Female
Humans
Hypertension / drug therapy*
Pregnancy
Pregnancy Complications, Cardiovascular / drug therapy*
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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