| Taking angiotensin-converting enzyme inhibitors during pregnancy: is it safe? | |
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MedLine Citation:
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PMID: 22267620 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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QUESTION: One of my 35-year-old pregnant patients has been treated with enalapril for primary hypertension. She learned she was pregnant at 11 weeks' gestation. I read somewhere that angiotensin-converting enzyme (ACE) inhibitors can cause malformations. What advice do you give to Motherisk callers? ANSWER: Most published studies have failed to show an effect of ACE inhibitors on congenital malformations. A recent systematic review and meta-analysis conducted by Motherisk does not suggest increased fetal risk of malformations. However, ACE inhibitors should be avoided in late pregnancy, as they might cause renal failure and acalvaria in the baby. |
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Authors:
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Almundher Al-Maawali; Asnat Walfisch; Gideon Koren |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Canadian family physician Médecin de famille canadien Volume: 58 ISSN: 1715-5258 ISO Abbreviation: Can Fam Physician Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-23 Completed Date: 2012-08-16 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 0120300 Medline TA: Can Fam Physician Country: Canada |
Other Details:
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Languages: eng Pagination: 49-51 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angiotensin-Converting Enzyme Inhibitors / adverse effects* Antihypertensive Agents / adverse effects* Congenital Abnormalities / etiology* Female Humans Hypertension / drug therapy* Pregnancy Pregnancy Complications, Cardiovascular / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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