Document Detail

Taking pressure off the heart: the ins and outs of atrophic remodelling.
MedLine Citation:
PMID:  21354996     Owner:  NLM     Status:  MEDLINE    
Our work on atrophic remodelling of the heart has led us to appreciate the simple principles in biology: (i) the dynamic nature of intracellular protein turnover, (ii) the return to the foetal gene programme when the heart remodels, and (iii) the adaptive changes of cardiac metabolism. Although the molecular mechanisms of cardiac hypertrophy are many, much less is known regarding the molecular mechanisms of cardiac atrophy. We state the case that knowing more about mechanisms of atrophic remodelling may provide insights into cellular consequences of metabolic and haemodynamic unloading of the stressed heart. Overall we strive to find an answer to the question: 'What makes the failing heart shrink and become stronger?' We speculate that signals arising from intermediary metabolism of energy-providing substrates are likely candidates.
Kedryn K Baskin; Heinrich Taegtmeyer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-02-25
Journal Detail:
Title:  Cardiovascular research     Volume:  90     ISSN:  1755-3245     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-19     Completed Date:  2011-08-17     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  243-50     Citation Subset:  IM    
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MeSH Terms
Cardiomegaly* / metabolism,  pathology,  physiopathology
Energy Metabolism / physiology
Hemodynamics / physiology*
Myocardium / metabolism*,  pathology*
Ventricular Remodeling / physiology*
Grant Support

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