| Taking pressure off the heart: the ins and outs of atrophic remodelling. | |
| | |
MedLine Citation:
|
PMID: 21354996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Our work on atrophic remodelling of the heart has led us to appreciate the simple principles in biology: (i) the dynamic nature of intracellular protein turnover, (ii) the return to the foetal gene programme when the heart remodels, and (iii) the adaptive changes of cardiac metabolism. Although the molecular mechanisms of cardiac hypertrophy are many, much less is known regarding the molecular mechanisms of cardiac atrophy. We state the case that knowing more about mechanisms of atrophic remodelling may provide insights into cellular consequences of metabolic and haemodynamic unloading of the stressed heart. Overall we strive to find an answer to the question: 'What makes the failing heart shrink and become stronger?' We speculate that signals arising from intermediary metabolism of energy-providing substrates are likely candidates. |
| | |
Authors:
|
Kedryn K Baskin; Heinrich Taegtmeyer |
Related Documents
:
|
7617506 - Ruptured interventricular septum after blunt chest trauma: ultrasonographic diagnosis. 11348606 - Right and left atrial activation during external direct-current cardioversion shocks de... 20381726 - The role of echocardiography in hemodynamic assessment of septic shock. 6723316 - Diffuse left ventricular hypokinesis in cardiogenic shock--its cause or consequence? 8324816 - Successful use of the right brachial approach to perform directional atherectomy of the... 18504616 - K(atp) channel polymorphism is associated with left ventricular size in hypertensive in... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2011-02-25 |
Journal Detail:
|
Title: Cardiovascular research Volume: 90 ISSN: 1755-3245 ISO Abbreviation: Cardiovasc. Res. Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-04-19 Completed Date: 2011-08-17 Revised Date: 2013-02-07 |
Medline Journal Info:
|
Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: England |
Other Details:
|
Languages: eng Pagination: 243-50 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Division of Cardiology, The University of Texas School of Medicine at Houston, 6431 Fannin, MSB 1.246, Houston, TX 77030, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Atrophy Cardiomegaly* / metabolism, pathology, physiopathology Energy Metabolism / physiology Hemodynamics / physiology* Humans Myocardium / metabolism*, pathology* Ventricular Remodeling / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
R01 HL061483/HL/NHLBI NIH HHS; R01 HL061483/HL/NHLBI NIH HHS; R01 HL061483-11/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vascular smooth muscle Jak2 mediates angiotensin II-induced hypertension via increased levels of rea...
Next Document: Comparison of IL-10 and MCP-1 7ND Gene Transfer with AAV9 Vectors for Protection from Murine Autoimm...