| Takayasu's arteritis in Turkey - clinical and angiographic features of 248 patients. | |
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MedLine Citation:
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PMID: 19646348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Takayasu's arteritis (TA) is a chronic, inflammatory vasculitis affecting the aorta and its major branches. Although it is more prevalent in Far-East Asia, the distribution of the disease is worldwide with different vascular involvement patterns and clinical manifestations. The objective of this study was to evaluate the demographic, clinical, angiographic and prognostic features of TA patients in Turkey. METHODS: Clinical and angiographic findings of 248 TA patients (228 female, 27 male) followed at 15 Rheumatology Centers were prospectively evaluated according to a predefined protocol. RESULTS: The mean age was 40.1 years (30.2 years at the clinical onset). Clinical manifestations included constitutional symptoms in 66%, absent or diminished pulses in 88%, bruits in 77%, extremity pain in 69%, claudication in 48%, hypertension in 43% and cerebrovascular accidents (CVA) in 18% of the patients. Renal artery stenosis, aortic regurgitation and pulmonary hypertension were present in 26%, 33% and 12%, respectively. According to the new angiographic classification, type V (50.8%) and Type I (32%) were the most frequent types of involvement. Corticosteroids were the main treatment in 93% of the patients alone (9%) or in combination with immunosuppressive agents (84%). Most frequently preferred immunosuppressive agents were methotrexate (63%), azathioprine (22%) and cyclophosphamide (13%). Remission was observed at least once in 94% of the patients and sustained remission in 71% during follow-up. CONCLUSION: The demographical, clinical and angiographic findings of TA patients in our series were similar to those reported from Japan, Brazil and Colombia. Combination therapies with immunosuppressive agents were the preferred choice of treatment in Turkey. |
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Authors:
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M Bicakcigil; K Aksu; S Kamali; Z Ozbalkan; A Ates; O Karadag; H T E Ozer; E Seyahi; S Akar; F Onen; A Cefle; S Z Aydin; N Yilmaz; A M Onat; V Cobankara; E Tunc; M A Ozturk; I Fresko; Y Karaaslan; N Akkoc; A E Yücel; S Kiraz; G Keser; M Inanc; H Direskeneli |
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Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: Clinical and experimental rheumatology Volume: 27 ISSN: 0392-856X ISO Abbreviation: Clin. Exp. Rheumatol. Publication Date: 2009 Jan-Feb |
Date Detail:
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Created Date: 2009-08-03 Completed Date: 2010-02-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8308521 Medline TA: Clin Exp Rheumatol Country: Italy |
Other Details:
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Languages: eng Pagination: S59-64 Citation Subset: IM |
Affiliation:
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Department of Rheumatology at Yeditepe University, Faculty of Medicine, Istanbul, Turkey. mbicakcigil@yeditepe.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age of Onset Aged Angiography Child Comorbidity Drug Therapy, Combination Female Glucocorticoids / therapeutic use* Humans Immunosuppressive Agents / therapeutic use* Male Middle Aged Prognosis Prospective Studies Remission Induction Takayasu Arteritis* / diagnosis, drug therapy, epidemiology, physiopathology Turkey / epidemiology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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