Document Detail


Takayasu's arteritis in Turkey - clinical and angiographic features of 248 patients.
MedLine Citation:
PMID:  19646348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Takayasu's arteritis (TA) is a chronic, inflammatory vasculitis affecting the aorta and its major branches. Although it is more prevalent in Far-East Asia, the distribution of the disease is worldwide with different vascular involvement patterns and clinical manifestations. The objective of this study was to evaluate the demographic, clinical, angiographic and prognostic features of TA patients in Turkey. METHODS: Clinical and angiographic findings of 248 TA patients (228 female, 27 male) followed at 15 Rheumatology Centers were prospectively evaluated according to a predefined protocol. RESULTS: The mean age was 40.1 years (30.2 years at the clinical onset). Clinical manifestations included constitutional symptoms in 66%, absent or diminished pulses in 88%, bruits in 77%, extremity pain in 69%, claudication in 48%, hypertension in 43% and cerebrovascular accidents (CVA) in 18% of the patients. Renal artery stenosis, aortic regurgitation and pulmonary hypertension were present in 26%, 33% and 12%, respectively. According to the new angiographic classification, type V (50.8%) and Type I (32%) were the most frequent types of involvement. Corticosteroids were the main treatment in 93% of the patients alone (9%) or in combination with immunosuppressive agents (84%). Most frequently preferred immunosuppressive agents were methotrexate (63%), azathioprine (22%) and cyclophosphamide (13%). Remission was observed at least once in 94% of the patients and sustained remission in 71% during follow-up. CONCLUSION: The demographical, clinical and angiographic findings of TA patients in our series were similar to those reported from Japan, Brazil and Colombia. Combination therapies with immunosuppressive agents were the preferred choice of treatment in Turkey.
Authors:
M Bicakcigil; K Aksu; S Kamali; Z Ozbalkan; A Ates; O Karadag; H T E Ozer; E Seyahi; S Akar; F Onen; A Cefle; S Z Aydin; N Yilmaz; A M Onat; V Cobankara; E Tunc; M A Ozturk; I Fresko; Y Karaaslan; N Akkoc; A E Yücel; S Kiraz; G Keser; M Inanc; H Direskeneli
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  27     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2009 Jan-Feb
Date Detail:
Created Date:  2009-08-03     Completed Date:  2010-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  S59-64     Citation Subset:  IM    
Affiliation:
Department of Rheumatology at Yeditepe University, Faculty of Medicine, Istanbul, Turkey. mbicakcigil@yeditepe.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age of Onset
Aged
Angiography
Child
Comorbidity
Drug Therapy, Combination
Female
Glucocorticoids / therapeutic use*
Humans
Immunosuppressive Agents / therapeutic use*
Male
Middle Aged
Prognosis
Prospective Studies
Remission Induction
Takayasu Arteritis* / diagnosis,  drug therapy,  epidemiology,  physiopathology
Turkey / epidemiology
Young Adult
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Immunosuppressive Agents

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