Document Detail

Takayasu's arteritis: a cause of prolonged arterial stiffness.
MedLine Citation:
PMID:  16403827     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Cardiovascular disease is a major cause of mortality and morbidity in patients with Takayasu's arteritis (TA). Increased arterial stiffness is an independent risk factor and predictor of cardiovascular mortality in a variety of diseases. Pulse wave velocity (PWV) and the augmentation index (AI) are used as clinical measurements of arterial stiffness. METHODS: Data are presented from 10 patients with TA and 11 normal controls obtained between 2000 and 2004. Arterial compliance was assessed non-invasively by measurement of PWV, using the Complior system, and calculation of the aortic AI. RESULTS: TA patients (mean age 40.8+/-13.2 yr) were compared with a control group of healthy women from a parallel study (mean age 32.3+/-5.5 yr). The mean carotid-femoral PWV (PWV-CF) was higher in TA patients (P = 0.03). In addition, both aortic AI derived from the radial artery (P = 0.002) and carotid AI (P = 0.03) were higher in TA patients compared with controls. PWV-CF did not correlate with CRP (r = - 0.23, P = 0.23) or ESR (r = - 0.19, P = 0.27). Similar results were obtained for the correlation of carotid-radial PWV with CRP (r = 0.15, P = 0.32) and ESR (r = 0.33, P = 0.14). CONCLUSIONS: Our data show that TA is associated with elevated arterial stiffness in the central aorta, which may persist when the disease is quiescent. These data suggest that PWV represents a means by which cardiovascular risk can be detected and monitored in TA, and highlights the importance of effective management of cardiovascular risk factors in these patients.
W F Ng; F Fantin; C Ng; F Dockery; R Schiff; K A Davies; C Rajkumar; J C Mason
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-10
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  45     ISSN:  1462-0324     ISO Abbreviation:  Rheumatology (Oxford)     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-22     Completed Date:  2006-08-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  England    
Other Details:
Languages:  eng     Pagination:  741-5     Citation Subset:  AIM; IM    
Rheumatology Section, Eric Bywaters Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK.
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MeSH Terms
Arteries / physiopathology*
Blood Flow Velocity
Blood Sedimentation
C-Reactive Protein / analysis
Middle Aged
Pulsatile Flow
Takayasu Arteritis / blood,  physiopathology*
Vascular Resistance
Reg. No./Substance:
9007-41-4/C-Reactive Protein

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