Document Detail

Takayasu's arteritis. Clinical study of 107 cases.
MedLine Citation:
PMID:  12655     Owner:  NLM     Status:  MEDLINE    
The clinical experience derived from the retrospective study of 107 cases of TA over a 19 year period is presented. The disease predominated in females (8.5:1), with age of onset usually less than 20 years. In half of the cases an acute inflammatory phase was observed, characterized mainly by systemic and cardiovascular symptoms. Subsequently the natural course of TA was toward chronicity with gradual deterioration. The most frequent variety of TA (65 per cent of the patients) was Type III, in which the supra-aortic trunks and the abdominal aorta were involved. The predominant clinical features were reduction of amplitude of peripheral arterial pulses (96 per cent), vascular bruits (94 per cent), and raised blood pressure (72 per cent), mainly resulting from renal arterial involvement (62 per cent). Heart failure (28 per cent) is rarely the result of direct coronary arteritis. TA is most often confused with aortic coarctation, but usually the aortogram distinguishes these. The etiology of TA is discussed. The high incidence of previous and present active tuberculous (48 per cent) in the present series and previous experimental work suggest that tuberculosis may play an important role in the etiology of TA. Treatment for antihypertension and heart failure should be employed when indicated. Treatment with corticosteroids requires further evaluation. Treatment for tuberculosis is not justified in all cases until the exact role of tuberculosis is well established.
E Lupi-Herrera; G Sánchez-Torres; J Marcushamer; J Mispireta; S Horwitz; J E Vela
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  93     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1977 Jan 
Date Detail:
Created Date:  1977-02-16     Completed Date:  1977-02-16     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  94-103     Citation Subset:  AIM; IM    
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MeSH Terms
Acute Disease
Aorta / pathology
Aorta, Abdominal / pathology
Aorta, Thoracic / pathology
Aortic Arch Syndromes / diagnosis*
Arteries / pathology
Arteritis / classification,  diagnosis*,  pathology
Child, Preschool
Chronic Disease
Middle Aged
Takayasu Arteritis / classification,  diagnosis*,  pathology

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