| Takayasu myocarditis mediated by cytotoxic T lymphocytes. | |
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MedLine Citation:
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PMID: 15805718 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 15-year-old Japanese man was referred for evaluation of heart failure. Conventional heart failure therapy had little effect, and severe left ventricular dysfunction as well as elevated erythrocyte sedimentation rate persisted. Magnetic resonance angiography showed aortic dilatation with wall thickening characteristic of Takayasu's arteritis. An endomyocardial biopsy specimen revealed infiltration of natural killer cells and gamma delta T lymphocytes, which play major roles in vascular injury of Takayasu's arteritis. Prednisolone administration provided great benefits to cardiac function. These findings suggest that autoimmune cytotoxic mechanisms similar to those in arterial tissue may contribute to cardiac impairment in Takayasu's arteritis. |
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Authors:
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Norifumi Takeda; Toshiyuki Takahashi; Yoshinori Seko; Koji Maemura; Hideki Nakasone; Kei Sakamoto; Yasunobu Hirata; Ryozo Nagai |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 44 ISSN: 0918-2918 ISO Abbreviation: Intern. Med. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-04-04 Completed Date: 2005-06-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 256-60 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8655. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Biopsy Follow-Up Studies Glucocorticoids / therapeutic use Humans Magnetic Resonance Angiography Male Myocarditis / diagnosis, drug therapy, immunology* Myocardium / pathology Prednisolone / therapeutic use T-Lymphocyte Subsets / immunology* T-Lymphocytes, Cytotoxic / immunology* Takayasu Arteritis / complications*, diagnosis, immunology Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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