Document Detail

Takayasu arteritis and cutaneous necrotizing vasculitis.
MedLine Citation:
PMID:  10773704     Owner:  NLM     Status:  MEDLINE    
Takayasu arteritis (TA) is an inflammatory arteriopathy involving predominantly the aorta and its main branches. The disease evolves in two phases: a first, nonspecific inflammatory stage and a late 'pulseless' stage, in which complications related to arterial stenosis and aneurysm formation predominate. In both phases, skin manifestations, such as inflammatory nodules, erythema-nodosum- and pyoderma-gangrenosum-like ulcers, have been described. We report 2 patients with TA, who had cutaneous necrotizing vasculitis as presenting manifestation of the disease. A review of the literature revealed 8 similar cases. TA does not only involve large arteries, but also small blood vessels. The observation that in TA the inflammatory process of the large arteries affects regions of the walls supplied by the vasa vasorum, the anatomy of which bears resemblance to the cutaneous vessel system, suggests that primary involvement of small vessels contributes to the development of the clinicopathological features of TA. Knowledge of the skin manifestations associated with TA remains important for its diagnosis and prompt instauration of life-saving treatment.
A M Skaria; P Ruffieux; P Piletta; P Chavaz; J H Saurat; L Borradori
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  200     ISSN:  1018-8665     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  2000  
Date Detail:
Created Date:  2000-06-27     Completed Date:  2000-06-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  139-43     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Department of Dermatology, University Medical Hospital, DHURDV, Geneva, Switzerland.
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MeSH Terms
Middle Aged
Skin / pathology
Skin Diseases, Vascular / complications*,  pathology
Takayasu Arteritis / complications*,  pathology
Vasculitis / complications*,  pathology

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