Document Detail

The Taiwanese hepatitis C virus genome: sequence determination and mapping the 5' termini of viral genomic and antigenomic RNA.
MedLine Citation:
PMID:  1314449     Owner:  NLM     Status:  MEDLINE    
The complete nucleotide sequence of hepatitis C virus (HCV) cloned from the liver tissue of a Taiwanese patient with post-transfusion type C hepatitis was determined. The 5' end of HCV genomic RNA was located 341 nucleotides upstream from the initiation codon for the viral polyprotein open reading frame. The 5' end of the viral antigenomic RNA was shown to have 13 consecutive As. Thus the 3' terminus of the viral genome is a stretch of U which ends about 50 nucleotides downstream from the stop codon of the large open reading frame. The nucleotide sequence homology between this HCV strain and two Japanese isolates was 90.5 and 90.7%, respectively. Homology with the United States strain, however, was only 77.8%. Accordingly, the indigenous Taiwanese HCV strain is of the same subtype as the Japanese isolates. Novel features of the viral genome termini are possibly relevant to HCV genome replication.
P J Chen; M H Lin; K F Tai; P C Liu; C J Lin; D S Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Virology     Volume:  188     ISSN:  0042-6822     ISO Abbreviation:  Virology     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-05-15     Completed Date:  1992-05-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0110674     Medline TA:  Virology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  102-13     Citation Subset:  IM    
Graduate Institute of Clinical Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei.
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MeSH Terms
Amino Acid Sequence
Base Sequence
Blotting, Southern
Cloning, Molecular
DNA, Viral
Genome, Viral*
Hepacivirus / genetics*
Hepatitis C / microbiology
Molecular Sequence Data
Polymerase Chain Reaction
RNA, Antisense / genetics*
RNA, Viral / genetics*
Restriction Mapping
Sequence Homology, Nucleic Acid
Reg. No./Substance:
0/DNA, Viral; 0/RNA, Antisense; 0/RNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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