Document Detail


Tailoring to RB: tumour suppressor status and therapeutic response.
MedLine Citation:
PMID:  18685599     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The retinoblastoma tumour suppressor (RB) is a crucial regulator of cell-cycle progression that is invoked in response to a myriad of anti-mitogenic signals. It has been hypothesized that perturbations of the RB pathway confer a synonymous proliferative advantage to tumour cells; however, recent findings demonstrate context-specific outcomes associated with such lesions. Particularly, loss of RB function is associated with differential response to wide-ranging therapeutic agents. Thus, the status of this tumour suppressor may be particularly informative in directing treatment regimens.
Authors:
Erik S Knudsen; Karen E Knudsen
Related Documents :
1777599 - Human interleukin-4: an immunomodulator with potential therapeutic applications.
19223899 - Taurine: a potential marker of apoptosis in gliomas.
12140379 - Cimetidine and a tamoxifen derivate reduce tumour formation in scid mice xenotransplant...
20535519 - The role of epidermal growth factor receptor in photodynamic therapy: a review of the l...
14632759 - Pleiotropic effects of cxc chemokines in gastric carcinoma: differences in cxcl8 and cx...
2595659 - Factors of the extrinsic pathway of blood coagulation in tumour associated macrophages.
9590129 - Down-regulation of c-myc and bcl-2 gene expression in pu.1-induced apoptosis in murine ...
16167069 - A novel antiapoptotic mechanism based on interference of fas signaling by cd44 variant ...
1393189 - Asymmetrical brain modulation of the immune response.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2008-8-07
Journal Detail:
Title:  Nature reviews. Cancer     Volume:  -     ISSN:  1474-1768     ISO Abbreviation:  Nat. Rev. Cancer     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-8-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101124168     Medline TA:  Nat Rev Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Erik S. Knudsen and Karen E. Knudsen are at the Department of Cancer Biology, and Karen E. Knudsen is at the Department of Urology, Kimmel Cancer Center, Bluemle Life Science Building-Room 1002, 233 South 10th Street, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. eknudsen@kimmelcancercenter.org kknudsen@kimmelcancercenter.org.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Diet and cancer prevention: the roles of observation and experimentation.
Next Document:  Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.