Document Detail

Tailoring to RB: tumour suppressor status and therapeutic response.
MedLine Citation:
PMID:  18685599     Owner:  NLM     Status:  Publisher    
The retinoblastoma tumour suppressor (RB) is a crucial regulator of cell-cycle progression that is invoked in response to a myriad of anti-mitogenic signals. It has been hypothesized that perturbations of the RB pathway confer a synonymous proliferative advantage to tumour cells; however, recent findings demonstrate context-specific outcomes associated with such lesions. Particularly, loss of RB function is associated with differential response to wide-ranging therapeutic agents. Thus, the status of this tumour suppressor may be particularly informative in directing treatment regimens.
Erik S Knudsen; Karen E Knudsen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2008-8-07
Journal Detail:
Title:  Nature reviews. Cancer     Volume:  -     ISSN:  1474-1768     ISO Abbreviation:  Nat. Rev. Cancer     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-8-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101124168     Medline TA:  Nat Rev Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Erik S. Knudsen and Karen E. Knudsen are at the Department of Cancer Biology, and Karen E. Knudsen is at the Department of Urology, Kimmel Cancer Center, Bluemle Life Science Building-Room 1002, 233 South 10th Street, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
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