Document Detail


Tailoring the swelling pressure of degrading dextran hydroxyethyl methacrylate hydrogels.
MedLine Citation:
PMID:  12741786     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Swelling pressure measurements were performed on degrading dextran hydroxyethyl methacrylate (dex-HEMA) hydrogels. In these networks, the cross-links are hydrolyzable carbonate ester bonds formed between methacrylate groups and dextran molecules. It is demonstrated that dex-HEMA gels made in the presence of a known amount of free dextran chains exhibit osmotic properties similar to those of partially degraded dex-HEMA gels. The swelling pressure, Pi(sw), of degrading dex-HEMA gels is controlled primarily by the cross-linked dex-HEMA polymer and the free dextran molecules, while the contribution of short poly-HEMA fragments (produced in the degradation process) is negligible. It is found that Pi(sw) only slightly changes during the first 15 days of degradation. Close to the end of the degradation process, however, a much faster increase in Pi(sw) is observed. The swelling pressure profile of these gels strongly depends on the concentration of the cross-linked dex-HEMA and its chemical composition (amount of HEMA groups per 100 glucose units).
Authors:
Barbara G Stubbe; Ferenc Horkay; Brian Amsden; Wim E Hennink; Stefaan C De Smedt; Jo Demeester
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomacromolecules     Volume:  4     ISSN:  1525-7797     ISO Abbreviation:  Biomacromolecules     Publication Date:    2003 May-Jun
Date Detail:
Created Date:  2003-05-13     Completed Date:  2004-01-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100892849     Medline TA:  Biomacromolecules     Country:  United States    
Other Details:
Languages:  eng     Pagination:  691-5     Citation Subset:  IM    
Affiliation:
Laboratory of General Biochemistry and Physical Pharmacy, Department of Pharmaceutics, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Biodegradation, Environmental
Dextrans / chemistry*,  metabolism
Hydrogels / chemistry*,  metabolism
Methylmethacrylates / chemistry*,  metabolism
Pressure
Chemical
Reg. No./Substance:
0/Hydrogels; 0/Methylmethacrylates; 21982-30-9/hydroxymethylmethacrylate; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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