Document Detail

Tailoring nanocrystalline diamond coated on titanium for osteoblast adhesion.
MedLine Citation:
PMID:  20540097     Owner:  NLM     Status:  MEDLINE    
Diamond coatings with superior chemical stability, antiwear, and cytocompatibility properties have been considered for lengthening the lifetime of metallic orthopedic implants for over a decade. In this study, an attempt to tailor the surface properties of diamond films on titanium to promote osteoblast (bone forming cell) adhesion was reported. The surface properties investigated here included the size of diamond surface features, topography, wettability, and surface chemistry, all of which were controlled during microwave plasma enhanced chemical-vapor-deposition (MPCVD) processes using CH4-Ar-H2 gas mixtures. The hardness and elastic modulus of the diamond films were also determined. H2 concentration in the plasma was altered to control the crystallinity, grain size, and topography of the diamond coatings, and specific plasma gases (O2 and NH3) were introduced to change the surface chemistry of the diamond coatings. To understand the impact of the altered surface properties on osteoblast responses, cell adhesion tests were performed on the various diamond-coated titanium. The results revealed that nanocrystalline diamond (grain sizes <100 nm) coated titanium dramatically increased surface hardness, and the introduction of O2 and NH3 during the MPCVD process promoted osteoblast adhesion on diamond and, thus, should be further studied for improving orthopedic applications.
Rajesh Pareta; Lei Yang; Abhishek Kothari; Sirivisoot Sirinrath; Xingcheng Xiao; Brian W Sheldon; Thomas J Webster
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biomedical materials research. Part A     Volume:  95     ISSN:  1552-4965     ISO Abbreviation:  J Biomed Mater Res A     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-26     Completed Date:  2010-12-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234237     Medline TA:  J Biomed Mater Res A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  129-36     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.
Division of Engineering, Brown University, Providence, Rhode Island 02912, USA.
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MeSH Terms
Cell Adhesion / drug effects
Coated Materials, Biocompatible / pharmacology*
Diamond / pharmacology*
Elastic Modulus / drug effects
Hardness / drug effects
Materials Testing / methods*
Microscopy, Atomic Force
Nanoparticles / chemistry*,  ultrastructure
Osteoblasts / cytology*,  drug effects*
Spectrum Analysis, Raman
Staining and Labeling
Surface Properties / drug effects
Titanium / pharmacology*
Water / chemistry
Reg. No./Substance:
0/Coated Materials, Biocompatible; 7440-32-6/Titanium; 7732-18-5/Water; 7782-40-3/Diamond

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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