| Tailoring treatment duration to 12 to 16 weeks in hepatitis C genotype 2 or 3 with rapid virologic response: systematic review and meta-analysis of randomized controlled trials. | |
| | |
MedLine Citation:
|
PMID: 20375729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND AIMS: Current treatment for genotype (GT) 2 or 3 hepatitis C virus infection is pegylated interferon and ribavirin (RBV) 800 mg/d for 24 weeks. This meta-analysis was carried out to assess whether the treatment duration can be reduced in patients with rapid virologic response (RVR) METHODS: Literature was searched for studies comparing short-term (12 to 16 wk) and 24 weeks treatment in GT 2 or 3 with RVR. RESULTS: Six studies (n=2434) were included and data on end-of-treatment response (ETR), sustained virologic response (SVR), and relapse rates (RR) were obtained. Pooled odds ratio (95% CI) for SVR and RR were 0.54 (0.35-0.85; P=0.008) and 3.12 (1.99-4.91; P<0.00001) favoring 24 weeks of treatment. Reducing treatment duration to 12 to 16 weeks and retreating relapses for 24 weeks was cost-effective. CONCLUSIONS: Reducing treatment duration to 12 to 16 weeks for GT 2 or 3 HCV patients with RVR is associated with a lower SVR and a higher RR. Advantages of short-term treatment include better patient compliance, lower rate of adverse effects, and cost. Short-term treatment may be an option for patients unable to tolerate treatment. Further studies are needed to identify factors predicting relapse with short-term treatment in GT 2 or 3 patients with RVR. |
| | |
Authors:
|
Ashwani K Singal; Bhupinder S Anand |
Related Documents
:
|
6870649 - Interferon therapy for laryngeal papillomatosis in adults. 19357529 - Simplification of antiretroviral therapy to a single-tablet regimen consisting of efavi... 20581879 - Prospective comparison of pcr-based vs late mrna-based preemptive antiviral therapy for... 9310219 - Physician concurrence with primary care guidelines for persons with hiv disease. 11177479 - The absence of hyperbilirubinaemia is highly predictive of treatment failure in advance... 6505269 - High dose rdna human alpha 2 interferon therapy in patients with advanced colorectal ad... 6997319 - A modification of the lapidus operation for hallux valgus. 8294749 - Repair and/or reconstruction of scapholunate interosseous ligament in lunate and perilu... 22748849 - Use of fibrin based biological adhesives in the prevention of anastomotic leaks in the ... |
Publication Detail:
|
Type: Journal Article; Meta-Analysis; Review |
Journal Detail:
|
Title: Journal of clinical gastroenterology Volume: 44 ISSN: 1539-2031 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-08-20 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: United States |
Other Details:
|
Languages: eng Pagination: 583-7 Citation Subset: IM |
Affiliation:
|
Department of Gastroenterology and Hepatology, University of Texas Medical Branch, Galveston, TX 77555-0764, USA. aksingal@utmb.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antiviral Agents / administration & dosage*, adverse effects, therapeutic use Drug Administration Schedule Drug Costs Drug Therapy, Combination Female Genotype Hepacivirus / drug effects*, genetics Hepatitis C / drug therapy*, virology Humans Interferon Alfa-2a / administration & dosage, adverse effects, therapeutic use Interferon Alfa-2b / administration & dosage, adverse effects, therapeutic use Male Medication Adherence Middle Aged Polyethylene Glycols / administration & dosage, adverse effects, therapeutic use Randomized Controlled Trials as Topic Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Antiviral Agents; 0/Polyethylene Glycols; 0/peginterferon alfa-2a; 0/peginterferon alfa-2b; 76543-88-9/Interferon Alfa-2a; 99210-65-8/Interferon Alfa-2b |
| Comments/Corrections | |
Comment In:
|
J Clin Gastroenterol. 2010 Sep;44(8):527-8
[PMID:
20628314
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neuroendocrine tumors of the gallbladder: an evaluation and reassessment of management strategy.
Next Document: Irritable bowel syndrome and chronic pelvic pain: a population-based study.