| Tail skin vasodilatation and bath test in capsaicin-desensitized rats. | |
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MedLine Citation:
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PMID: 7191981 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vasodilatation in response to heat, the role of tail vasodilatation in thermolysis and the ability of the animals to use free water for evaporative cooling were studied in control and capsaicin-desensitized rats. 1) While vasodilatation in the tail began in the controls as soon as their temperatures reached 38.5-39 degrees C, in most of the desensitized rats the onset of this reaction was above a body temperature of 40 degrees C. 2) When exposed to 32 degrees C, desalivated capsaicin-treated rats showed a significant hyperthermia as compared to the controls. If the tails were amputated too, the temperatures of the controls rose to near those of the desensitized animals. 3) In the case of prolonged heat exposure or at a higher ambient temperature (38 degrees C), the desalivated tail-amputated controls still remained more tolerant to heat than the desensitized rats. 4) Even at an ambient temperature of 38 degrees C, desalivated controls without tails exhibited excellent thermoregulation when a water bath was present; they used the free water for evaporation. Capsaicin-treated rats neglected the water bath, and their temperatures rose continuously. 5) The results suggests that capsaicin treatment impaired reflex vasodilatation to heat and the behaviour of using free water for heat dissipation. |
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Authors:
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F Obál; G Benedek; A Jancsó-Gábor; F Obál |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pflügers Archiv : European journal of physiology Volume: 387 ISSN: 0031-6768 ISO Abbreviation: Pflugers Arch. Publication Date: 1980 Sep |
Date Detail:
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Created Date: 1981-01-29 Completed Date: 1981-01-29 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 183-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Capsaicin / pharmacology* Drug Tolerance Fatty Acids, Unsaturated / pharmacology* Hot Temperature Male Rats Regional Blood Flow Salivary Glands / physiology Skin / blood supply Tail / blood supply Vasodilation / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Unsaturated; 404-86-4/Capsaicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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