Document Detail


Tai chi exercise in patients with chronic heart failure: a randomized clinical trial.
MedLine Citation:
PMID:  21518942     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Preliminary evidence suggests that meditative exercise may have benefits for patients with chronic systolic heart failure (HF); this has not been rigorously tested in a large clinical sample. We sought to investigate whether tai chi, as an adjunct to standard care, improves functional capacity and quality of life in patients with HF.
METHODS: A single-blind, multisite, parallel-group, randomized controlled trial evaluated 100 outpatients with systolic HF (New York Heart Association class I-III, left ventricular ejection fraction ≤40%) who were recruited between May 1, 2005, and September 30, 2008. A group-based 12-week tai chi exercise program (n = 50) or time-matched education (n = 50, control group) was conducted. Outcome measures included exercise capacity (6- minute walk test and peak oxygen uptake) and disease-specific quality of life (Minnesota Living With Heart Failure Questionnaire).
RESULTS: Mean (SD) age of patients was 67 (11) years; baseline values were left ventricular ejection fraction, 29% (8%) and peak oxygen uptake, 13.5 mL/kg/min; the median New York Heart Association class of HF was class II. At completion of the study, there were no significant differences in change in 6-minute walk distance and peak oxygen uptake (median change [first quartile, third quartile], 35 [-2, 51] vs 2 [-7, 54] meters, P = .95; and 1.1 [-1.1, 1.5] vs -0.5 [-1.2, 1.8] mL/kg/min, P = .81) when comparing tai chi and control groups; however, patients in the tai chi group had greater improvements in quality of life (Minnesota Living With Heart Failure Questionnaire, -19 [-23, -3] vs 1 [-16, 3], P = .02). Improvements with tai chi were also seen in exercise self-efficacy (Cardiac Exercise Self-efficacy Instrument, 0.1 [0.1, 0.6] vs -0.3 [-0.5, 0.2], P < .001) and mood (Profile of Mood States total mood disturbance, -6 [-17, 1] vs -1 [-13, 10], P = .01).
CONCLUSION: Tai chi exercise may improve quality of life, mood, and exercise self-efficacy in patients with HF. Trial Registration clinicaltrials.gov Identifier: NCT00110227.
Authors:
Gloria Y Yeh; Ellen P McCarthy; Peter M Wayne; Lynne W Stevenson; Malissa J Wood; Daniel Forman; Roger B Davis; Russell S Phillips
Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Archives of internal medicine     Volume:  171     ISSN:  1538-3679     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-26     Completed Date:  2011-06-20     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  750-7     Citation Subset:  AIM; IM    
Affiliation:
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Brookline, MA 02446, USA. gyeh@bidmc.harvard.edu
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00110227
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MeSH Terms
Descriptor/Qualifier:
Affect
Aged
Aged, 80 and over
Biological Markers / blood
Comorbidity
Confounding Factors (Epidemiology)
Exercise Tolerance*
Female
Heart Failure / blood,  physiopathology*,  therapy*
Heart Rate
Humans
Male
Middle Aged
Outpatients
Oxygen Consumption
Patient Compliance
Quality of Life*
Questionnaires
Self Efficacy*
Severity of Illness Index
Single-Blind Method
Stroke Volume
Tai Ji*
Time Factors
Treatment Outcome
Walking
Grant Support
ID/Acronym/Agency:
K23 AT002624/AT/NCCAM NIH HHS; K23 AT002624-04/AT/NCCAM NIH HHS; R01 AT002454/AT/NCCAM NIH HHS; R01 AT002454-03/AT/NCCAM NIH HHS; RR 01032/RR/NCRR NIH HHS; U19 AT002022/AT/NCCAM NIH HHS; U19 AT002022-02/AT/NCCAM NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers
Comments/Corrections
Comment In:
Arch Intern Med. 2011 Oct 10;171(18):1685; author's reply 1685-6   [PMID:  21987204 ]
Arch Intern Med. 2011 Apr 25;171(8):758-9   [PMID:  21518943 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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