Document Detail

Tagging mammalian transcription complexity.
MedLine Citation:
PMID:  16859803     Owner:  NLM     Status:  MEDLINE    
The nature of the 'transcriptome' is more complex than first realized. Although CAGE, various tagging technologies and tiling arrays show that most of the mammalian genome is transcribed, a large proportion of transcripts do not encode proteins and are either poorly polyadenylated, involved in sense-antisense pairs or never leave the nucleus. In this article, I review the various techniques and data sets that are currently used to measure gene transcription and the evidence that reveals the true extent of transcription in mammalian genomes. The next few years will see efforts to identify novel transcripts systematically and decipher their function. A deeper understanding of transcriptional complexity might even lead us to redefine what we mean by the term 'gene'.
Piero Carninci
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-07-21
Journal Detail:
Title:  Trends in genetics : TIG     Volume:  22     ISSN:  0168-9525     ISO Abbreviation:  Trends Genet.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-22     Completed Date:  2006-12-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8507085     Medline TA:  Trends Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  501-10     Citation Subset:  IM    
Genome Science Laboratory, Discovery and Research Institute, RIKEN Wako Institute, 2-1 Hirosawa, Wako, Saitama 351-0198 Japan.
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MeSH Terms
Alternative Splicing
Cluster Analysis
DNA, Complementary / analysis
Gene Expression Profiling / methods*
Mammals / genetics,  metabolism
RNA, Messenger / metabolism
Reproducibility of Results
Sequence Tagged Sites*
Transcription, Genetic*
Reg. No./Substance:
0/DNA, Complementary; 0/RNA, Messenger

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