Document Detail


Taenia taeniaeformis: characterization of larval metabolic products and growth of host gastric cells in vitro.
MedLine Citation:
PMID:  6499997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Development of larvae of the cestode parasite Taenia taeniaeformis in the liver of rats induces gross hyperplasia of the gastric mucosa and excessive mucus production in the stomach without any direct contact with the stomach. Because the taeniid larvae are known to elaborate excretory-secretory (E-S) product in vivo and in vitro, the product was analyzed further, and its effects on cultured rat and dog stomach cells were investigated. In vitro E-S product contained less negatively charged glycosaminoglycan than either heparin or chondroitin sulfate, and proteins of various molecular weights. It stimulated the growth of both rat and dog stomach cells at concentrations of 3-9 micrograms protein/ml culture medium. At a concentration of 30 micrograms protein/ml culture medium, it stimulated hexosamine production in the cells up to 20 times, and multiple intracytoplasmic granules were found in both rat and dog cultured cells by light and electron microscopy. These results suggest that larval E-S product may be involved in the induction of gastric hyperplasia and hypermucus secretion.
Authors:
Y Rikihisa; T Letonja; N Pratt; Y Chin Lin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Experimental parasitology     Volume:  58     ISSN:  0014-4894     ISO Abbreviation:  Exp. Parasitol.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1984-12-31     Completed Date:  1984-12-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370713     Medline TA:  Exp Parasitol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  230-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Division
Cells, Cultured
Cytoplasmic Granules / ultrastructure
Dogs
Female
Gastric Mucosa / cytology*,  metabolism
Glycosaminoglycans / analysis*,  pharmacology
Hexosamines / biosynthesis
Larva / metabolism
Male
Proteins / analysis*,  pharmacology
Rats
Rats, Inbred Strains
Taenia / metabolism*
Chemical
Reg. No./Substance:
0/Glycosaminoglycans; 0/Hexosamines; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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