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Tadalafil for the treatment of pulmonary arterial hypertension.
MedLine Citation:
PMID:  21702653     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Tadalafil is a selective inhibitor of phosphodiesterase type-5 (PDE-5) that was originally developed for the treatment of male erectile dysfunction and recently approved for the treatment of pulmonary arterial hypertension (PAH). The antipulmonary hypertensive effects of nitric oxide and the natriuretic peptides are mediated via increasing intracellular cGMP and enzymatic degradation by PDE-5 is the major route of cGMP inactivation in the lung. Evidence is accruing that PDE-5 activity is increased in pulmonary vascular diseases and may contribute to the pathogenesis of PAH. The longer half-life of tadalafil allows for once-daily dosing as compared with three-times daily dosing for sildenafil, the only other PDE-5 inhibitor currently approved for treatment of PAH. This article reviews the role of cGMP and PDE-5 in PAH, presents the results of recent clinical trials and discusses the role of tadalafil in the treatment of this rare but difficult-to-treat disease.
Authors:
James R Klinger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of respiratory medicine     Volume:  5     ISSN:  1747-6356     ISO Abbreviation:  Expert Rev Respir Med     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278196     Medline TA:  Expert Rev Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  315-28     Citation Subset:  IM    
Affiliation:
Division of Pulmonary, Sleep and Critical Care Medicine, Rhode Island Hospital, Alpert Medical School, Brown University, 593 Eddy Street, Providence, RI 02903, USA. james_klinger@brown.edu.
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