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Tadalafil Prevents Acute Heart Failure with Reduced Ejection Fraction in Mice.
MedLine Citation:
PMID:  25322707     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: Phosphodiesterase-5 (PDE5) inhibitors were shown to exert powerful protection in various animal models of cardiomyopathy. Tadalafil is a long-acting and highly specific PDE5 inhibitor, which makes it the most attractive in its class for long-term management of patients with heart failure. We studied the effects of tadalafil in attenuating ischemic cardiomyopathy in mice.
METHODS AND RESULTS: Adult male mice underwent myocardial infarction (MI) by permanent left coronary artery ligation and were treated daily with tadalafil (1 mg/kg; ip) or volume-matched 10 % DMSO for 4 weeks. Twenty four hours after coronary ligation, infarct size, measured by TTC staining, was reduced from 70.1 ± 3.1 % in DMSO-treated group to 49.3 ± 2.6 % with tadalafil (P < 0.05). Similarly, tadalafil treatment yielded a smaller fibrotic area (8.8 ± 2.8 % of LV), assessed by Masson's trichrome staining, as compared to DMSO group (21.9 ± 3.9 %, P < 0.05). Apoptosis, measured by TUNEL assay, also declined with tadalafil (2.1 ± 0.2 %) as compared to DMSO (6.7 ± 0.4 %, P < 0.05) at 28 days post MI. Tadalafil also attenuated the increase in cardiac hypertrophy and pulmonary edema following infarction. These parameters reflect diminished left ventricular (LV) adverse remodeling and preserved fractional shortening with tadalafil at 7 and 28 days post infarction.
CONCLUSIONS: Tadalafil attenuates ischemic cardiomyopathy in mice and preserves LV function.
Authors:
Fadi N Salloum; Vinh Q Chau; Nicholas N Hoke; Rakesh C Kukreja
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-17
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  -     ISSN:  1573-7241     ISO Abbreviation:  Cardiovasc Drugs Ther     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-17     Completed Date:  -     Revised Date:  2014-10-18    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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