Document Detail

Tacrolimus-induced thrombotic microangiopathy: natural history of a severe, acute vasculopathy.
MedLine Citation:
PMID:  22185974     Owner:  NLM     Status:  In-Data-Review    
Calcineurin inhibitors (CNI) have been clearly associated with posttransplant thrombotic microangiopathy (PTTMA). We report a case of de novo PT-TMA involving predominantly small arteries and arterioles of a renal allograft in a patient receiving tacrolimus. Serial biopsies demonstrate the natural history of this lesion through the chronic nonspecific phase. The case is discussed in the context of a literature review of PT-TMA in general and CNI use in particular.
John M Carson; Eric D Newman; John L Farber; Edward J Filippone
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nephrology     Volume:  77     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  79-84     Citation Subset:  IM    
Department of Medicine, Division of Nephrology of the Department of Medicine, and Department of Pathology, Thomas Jefferson University Hospital, Philadelphia, PA , USA.
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