| Tacrolimus-induced HUS: an unusual cause of acute renal failure in nephrotic syndrome. | |
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MedLine Citation:
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PMID: 17123120 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute renal failure (ARF) is an uncommon complication in children with nephrotic syndrome. We report here the case of a 10-year-old male child with primary steroid-resistant nephrotic syndrome who was non-responsive to steroids and cyclophosphamide. A kidney biopsy revealed that he had focal segmental glomerulosclerosis. His treatment was initiated with tacrolimus (dose of 0.15 mg/kg/day) in two divided doses along with prednisolone 60 mg/m(2)/daily. After 1 month of treatment, he was diagnosed as having acute renal failure secondary to HUS. This was postulated to be due to the tacrolimus therapy, which was withdrawn. Two weeks after stopping the adminsitration of tacrolimus, his urine output improved, and the hemoglobin and serum creatinine normalized. Thus, tacrolimus-induced HUS is a rare cause of ARF in nephrotic syndrome. With the increasing use of tacrolimus in steroid-resistant nephrotic syndrome, the treating physicians need to be aware of this rare, but potentially life-threatening side effect. |
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Authors:
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Vinod Baburaj Pandirikkal; Manoj Jain; Sanjeev Gulati |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-11-23 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 22 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2006-12-20 Completed Date: 2007-04-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 298-300 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy Child Drug Resistance Glomerulosclerosis, Focal Segmental / complications, drug therapy Hemolytic-Uremic Syndrome / chemically induced*, complications* Humans Immunosuppressive Agents / adverse effects*, therapeutic use Kidney / pathology Kidney Failure, Acute / diagnosis, etiology* Male Nephrotic Syndrome / complications*, drug therapy Steroids / therapeutic use Tacrolimus / adverse effects*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 0/Steroids; 109581-93-3/Tacrolimus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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