| Tacrolimus in the treatment of idiopathic nephrotic syndrome. | |
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MedLine Citation:
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PMID: 17594193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The immunosuppressant tacrolimus (FK-506) is a calcineurin inhibitor with a widespread use for the prevention of graft rejection in transplantation medicine. Tacrolimus inhibits the activation of an essential transcription factor for the transcription of cytokine genes in T cells leading to a decreased production of cytokines such as IL-2 and IFN-gamma. As T-cell activation plays a crucial role in the pathogenesis of inflammatory glomerular diseases, there is an increasing number of reports on the use of tacrolimus in nephrotic syndrome. In idiopathic nephrotic syndrome, corticosteroid treatment constitutes the first-line therapy to achieve remission. In the case of steroid resistance or steroid dependence, alternative immunosuppressive strategies are needed. Cyclophosphamide and ciclosporin are well-established drugs in this condition. The present article reviews the pharmacodynamics, pharmacokinetics, safety and clinical efficacy of tacrolimus in steroid-resistant and steroid-dependent nephrotic syndrome. |
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Authors:
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Timm H Westhoff; Markus van der Giet |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert opinion on investigational drugs Volume: 16 ISSN: 1744-7658 ISO Abbreviation: Expert Opin Investig Drugs Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-27 Completed Date: 2007-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9434197 Medline TA: Expert Opin Investig Drugs Country: England |
Other Details:
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Languages: eng Pagination: 1099-110 Citation Subset: IM |
Affiliation:
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Charité--Campus Benjamin Franklin, Centrum 10--Nephrology, Hindenburgdamm 30, Berlin, Germany. timm.westhoff@charite.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biopsy, Needle Child, Preschool Dose-Response Relationship, Drug Drug Administration Schedule Drugs, Investigational* Female Follow-Up Studies Graft Rejection / prevention & control Humans Immunohistochemistry Immunosuppressive Agents / adverse effects, pharmacology, therapeutic use* Kidney Function Tests Kidney Transplantation / adverse effects, immunology Male Maximum Tolerated Dose Nephrotic Syndrome / diagnosis*, drug therapy* Risk Assessment Severity of Illness Index Tacrolimus / adverse effects, pharmacology, therapeutic use* Transplantation Immunology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Drugs, Investigational; 0/Immunosuppressive Agents; 109581-93-3/Tacrolimus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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