Document Detail

Tacrolimus hydrate (FK506): therapeutic effects and selection of responders in the treatment of myasthenia gravis.
MedLine Citation:
PMID:  14643908     Owner:  NLM     Status:  MEDLINE    
Tacrolimus hydrate (FK506) reduces myasthenic symptoms due to its immunosuppressive properties. We studied the therapeutic effects of FK506 and noted improvement in 7 of 13 myasthenic patients on the clinical muscle test (myasthenia gravis, MG score). Two other patients with relapsing ocular symptoms improved. We also examined patient sensitivity to FK506, but could not predict such sensitivity before FK506 treatment in the present study.
Nobuo Wakata; Toyokazu Saito; Sachiko Tanaka; Toshihiko Hirano; Kitaro Oka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  106     ISSN:  0303-8467     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-03-17     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  5-8     Citation Subset:  IM    
Fourth Department of Internal Medicine, Toho University School of Medicine, 2-17-6 Oohashi, Meguro-ku, Tokyo 153-8515, Japan.
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MeSH Terms
Combined Modality Therapy
Immunosuppressive Agents / adverse effects,  therapeutic use*
Middle Aged
Myasthenia Gravis / diagnosis,  drug therapy*,  immunology
Neurologic Examination / drug effects
Patient Selection*
Prednisolone / therapeutic use
Tacrolimus / adverse effects,  therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Immunosuppressive Agents; 109581-93-3/Tacrolimus; 50-24-8/Prednisolone

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